Dapagliflozin + Metformin Tablets

Therapeutic Indication

Type 2 diabetes mellitus (when diet, exercise, or monotherapy is insufficient)

Improves glycemic control as dual therapy

Adjunct in patients with cardiovascular risk factors

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Dapagliflozin

Tablet

This fixed-dose combination provides dual glycemic control in type 2 diabetes mellitus. Dapagliflozin, an SGLT2 inhibitor, promotes urinary glucose excretion, while Metformin, a biguanide, reduces hepatic glucose production and improves insulin sensitivity.

Speciality	Endocrinology \| Diabetology \| Internal Medicine
Tags	Type 2 Diabetes \| SGLT2 Inhibitor \| Biguanide \| Glycemic Control \| Combination Therapy
Strength	Dapagliflozin 5 mg/10 mg Metformin Hydrochloride 500 mg
Packing Size	10 Tablets

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Mechanism

Dapagliflozin: Inhibits sodium-glucose co-transporter 2 (SGLT2) in proximal renal tubules → increases urinary glucose excretion → lowers plasma glucose.
Metformin: Decreases hepatic gluconeogenesis, increases peripheral glucose uptake, and reduces intestinal glucose absorption.

Pharmacokinetics

Dapagliflozin Absorption: Oral bioavailability ~78%; peak plasma levels in 2 hrs.
Metformin Absorption: Peak plasma levels in 2–3 hrs; bioavailability ~50–60%.
Distribution: Dapagliflozin ~91% protein bound; Metformin not protein bound.
Metabolism: Dapagliflozin metabolized hepatically (UGT1A9); Metformin not metabolized.
Excretion: Dapagliflozin via urine and feces; Metformin via renal excretion unchanged.
Half-life: Dapagliflozin ~12 hrs; Metformin ~6 hrs.

Side Effects

Genital mycotic infections (dapagliflozin)
Urinary tract infections
Hypoglycemia (especially with other antidiabetics)
Gastrointestinal upset (metformin)
Rare: Lactic acidosis (metformin)

Contraindication

Type 1 diabetes mellitus
Diabetic ketoacidosis
Severe renal impairment (eGFR < 30 mL/min/1.73 m²)
Hypersensitivity to either component

Interaction

Alcohol ↑ risk of lactic acidosis (metformin)
Diuretics ↑ risk of dehydration and hypotension (dapagliflozin)
Other antidiabetics ↑ risk of hypoglycemia

Warning and Precautions

Monitor renal function regularly
Advise patients on genital hygiene to reduce infection risk
Take with meals to reduce GI upset

Dosage

As directed by the Physician.

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