Cyclophosphamide Tablets | Immunosuppressant Medicine

Therapeutic Indication

Immunosuppressant in autoimmune diseases

Prevention of organ transplant rejection

Cyclophosphamide

Tablet

Cyclophosphamide is an alkylating agent with immunosuppressive properties. It works by cross-linking DNA strands, leading to inhibition of cell replication and suppression of immune responses.

Speciality	Immunology \| Rheumatology \| Nephrology
Tags	Immunosuppressant \| Autoimmune Therapy \| Organ Transplant \| Alkylating Agent
Strength	50 mg
Packing Size	10 Tablets

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Mechanism

Cyclophosphamide is metabolized in the liver to active metabolites that form DNA cross-links, preventing replication and leading to suppression of immune cell activity.

Pharmacokinetics

Absorption: Well absorbed orally
Distribution: Widely distributed
Metabolism: Hepatic metabolism to active metabolites
Excretion: Renal excretion
Half-life: 3–12 hours

Side Effects

Myelosuppression (leukopenia, anemia)
Nausea, vomiting
Alopecia
Hemorrhagic cystitis

Contraindication

Pregnancy
Severe bone marrow suppression
Active infections
Hypersensitivity to cyclophosphamide

Interaction

Allopurinol: May increase risk of bone marrow suppression.
Other immunosuppressants: Additive toxicity.
Warfarin: May alter anticoagulant effect.

Warning and Precautions

Monitor blood counts regularly.
Ensure adequate hydration to prevent hemorrhagic cystitis.
Monitor liver and kidney function.
Use with caution in immunocompromised patients.

Dosage

As directed by the Physician.