Cisapride Tablets

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Therapeutic Indication

Gastroesophageal reflux disease (GERD)
Diabetic gastroparesis
Delayed gastric emptying
Functional dyspepsia
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Cisapride

Tablet

Cisapride is a prokinetic agent used to enhance gastrointestinal motility. It increases acetylcholine release in the enteric nervous system, improving esophageal clearance and gastric emptying. Due to cardiac risks, its use is restricted and requires strict medical supervision.

Speciality Gastroenterology
Tags GERD | Gastroparesis | Motility Disorder | Prokinetic
Strength
  • 5 mg
Packing Size
  • 10 Tablets

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Mechanism

Cisapride enhances acetylcholine release at the myenteric plexus, increasing lower esophageal sphincter tone and accelerating gastric emptying. This improves symptoms of reflux and delayed gastric transit.

Pharmacokinetics

  • Absorption: Rapidly absorbed orally.
  • Distribution: Widely distributed, protein-bound.
  • Metabolism: Hepatic metabolism via CYP3A4.
  • Elimination: Excreted in urine and feces.
  • Half-life: ~10 hours.

Side Effects

  • Headache
  • Nausea, diarrhea
  • Abdominal cramps
  • Dizziness
  • QT prolongation, arrhythmias (serious)

Contraindication

  • History of cardiac arrhythmias
  • Concomitant use with CYP3A4 inhibitors (azole antifungals, macrolides)
  • GI obstruction or perforation
  • Pregnancy and neonates

Interaction

  • Azole antifungals (ketoconazole, itraconazole)
  • Macrolide antibiotics (erythromycin, clarithromycin)
  • Protease inhibitors
  • Other QT-prolonging drugs

Warning and Precautions

  • Restricted use due to cardiac risks
  • Monitor ECG regularly
  • Avoid grapefruit juice (increases drug levels)
  • Use under strict medical supervision

Dosage

As directed by the Physician.

Disclaimer

All product details on this website are for reference and informational purposes only and are not directed at patients or consumers.
As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
Please consult a healthcare professional before using any medicinal product.