Cinnarizine + Domperidone Tablets

Project Image
Thumb Image
Thumb Image

Therapeutic Indication

Vertigo associated with vestibular disorders
Motion sickness
Nausea and vomiting
Adjunct therapy in Ménière’s disease
+91 85919 78885

Cinnarizine + Domperidone

Tablet

This combination provides dual action: Cinnarizine is an antihistamine and calcium channel blocker that reduces vestibular stimulation, while Domperidone is a dopamine antagonist that enhances gastrointestinal motility and prevents nausea and vomiting.

Speciality ENT | Neurology | Gastroenterology
Tags Vertigo | Motion Sickness | Antiemetic | Vestibular Disorders
Strength
  • Cinnarizine 20 mg
  • Domperidone 15 mg
Packing Size
  • 10 Tablets

Check all Tablet Range

Click to know More

Mechanism

Cinnarizine blocks histamine H1 receptors and inhibits calcium influx in vascular smooth muscle, reducing vestibular stimulation. Domperidone antagonizes dopamine D2 receptors in the chemoreceptor trigger zone and gastrointestinal tract, enhancing gastric emptying and preventing nausea.

Pharmacokinetics

  • Cinnarizine Absorption: Rapid oral absorption.
  • Domperidone Absorption: Oral bioavailability ~15% (first-pass metabolism).
  • Distribution: Both drugs widely distributed.
  • Metabolism: Hepatic metabolism (Domperidone via CYP3A4).
  • Elimination: Excreted in urine and feces.
  • Half-life: Cinnarizine ~3–6 hours; Domperidone ~7–9 hours.

Side Effects

  • Drowsiness
  • Dry mouth
  • Gastrointestinal discomfort
  • Extrapyramidal symptoms (rare, Domperidone)
  • Weight gain (long-term use)

Contraindication

  • Hypersensitivity to either component
  • Severe hepatic impairment
  • Cardiac arrhythmias (Domperidone)
  • Pregnancy and lactation — use cautiously

Interaction

  • CYP3A4 inhibitors (ketoconazole, erythromycin): Increase Domperidone levels.
  • Alcohol: Additive CNS depression with Cinnarizine.
  • Other antihistamines: Additive sedative effect.

Warning and Precautions

  • Advise patients to avoid driving due to drowsiness.
  • Monitor liver function during prolonged therapy.
  • Use cautiously in elderly patients.
  • Discontinue if extrapyramidal symptoms occur.

Dosage

As directed by the Physician.