Cinacalcet Tablets | Hyperparathyroidism & CKD Management

Therapeutic Indication

Secondary hyperparathyroidism in CKD patients on dialysis

Parathyroid carcinoma

Hypercalcemia due to primary hyperparathyroidism (when surgery is not suitable)

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Cinacalcet

Tablet

Cinacalcet is a calcimimetic agent that lowers parathyroid hormone (PTH) levels by increasing the sensitivity of calcium-sensing receptors on parathyroid cells.

Speciality	Nephrology \| Endocrinology \| Oncology
Tags	Hyperparathyroidism \| CKD \| Parathyroid Carcinoma \| Hypercalcemia
Strength	30 mg 60 mg 90 mg
Packing Size	10 Tablets

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Mechanism

Cinacalcet increases the sensitivity of calcium-sensing receptors on parathyroid cells, reducing PTH secretion and lowering serum calcium and phosphate levels.

Pharmacokinetics

Absorption: Well absorbed orally, enhanced with food.
Metabolism: Extensively metabolized in liver (CYP3A4, CYP2D6, CYP1A2).
Excretion: Primarily via urine and feces.
Half-life: ~30–40 hours.

Side Effects

Nausea
Vomiting
Hypocalcemia
Muscle cramps
Fatigue
Rare: Seizures

Contraindication

Hypocalcemia
Hypersensitivity to Cinacalcet

Interaction

Strong CYP3A4 inhibitors (ketoconazole, itraconazole)
CYP2D6 substrates (antidepressants, antiarrhythmics)

Warning and Precautions

Monitor serum calcium and PTH regularly
Use with caution in hepatic impairment
Not recommended in pediatric patients

Dosage

As directed by the Physician.