Cilnidipine Tablets

Therapeutic Indication

Hypertension (high blood pressure)

Cardiovascular protection

Adjunct therapy in angina

Renal protection in hypertensive patients

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Cilnidipine

Tablet

Cilnidipine is a novel calcium channel blocker that inhibits both L-type and N-type calcium channels. It lowers blood pressure by vasodilation and reduces sympathetic nerve activity, offering dual cardiovascular and renal protection.

Speciality	Cardiology \| Nephrology \| Antihypertensive
Tags	Hypertension \| Calcium Channel Blocker \| Cardiovascular Protection \| Renal Safety
Strength	5 mg 10 mg 20 mg
Packing Size	10 Tablets

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Mechanism

Cilnidipine blocks L-type calcium channels in vascular smooth muscle, causing vasodilation and lowering blood pressure. It also inhibits N-type calcium channels in sympathetic nerve endings, reducing norepinephrine release and sympathetic overactivity.

Pharmacokinetics

Absorption: Rapid oral absorption.
Distribution: Highly lipophilic, widely distributed.
Metabolism: Extensively metabolized in liver.
Elimination: Excreted via urine and feces.
Half-life: ~2–4 hours.

Side Effects

Dizziness
Headache
Peripheral edema
Flushing
Rare: hypotension, palpitations

Contraindication

Hypersensitivity to Cilnidipine
Severe hypotension
Cardiogenic shock
Pregnancy and lactation — use cautiously

Interaction

Other antihypertensives: Additive hypotensive effect.
Beta-blockers: May increase risk of bradycardia.
NSAIDs: May reduce antihypertensive efficacy.
CYP3A4 inhibitors: May increase plasma levels of Cilnidipine.

Warning and Precautions

Monitor blood pressure regularly.
Use cautiously in patients with hepatic impairment.
Advise patients to avoid abrupt discontinuation.
Adjust dose in elderly patients.