Chloroquine Phosphate Tablets

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Therapeutic Indication

Malaria treatment and prophylaxis
Amebiasis (extraintestinal)
Autoimmune disorders (rheumatoid arthritis, lupus)
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Chloroquine Phosphate

Tablet

Chloroquine phosphate is an antimalarial and anti-inflammatory drug. It works by interfering with parasite growth in red blood cells and modulating immune responses in autoimmune conditions.

Speciality Infectious Diseases | Rheumatology
Tags Malaria | Autoimmune | Antimalarial
Strength
  • 250 mg
Packing Size
  • 10 Tablets

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Mechanism

Chloroquine accumulates in parasite food vacuoles, interfering with heme detoxification and leading to parasite death. It also modulates immune activity by reducing cytokine release.

Pharmacokinetics

  • Absorption: Well absorbed orally.
  • Distribution: Widely distributed, concentrates in liver, spleen, kidney.
  • Metabolism: Hepatic metabolism.
  • Elimination: Excreted in urine.
  • Half-life: ~1–2 months (due to tissue binding).

Side Effects

  • Nausea, vomiting
  • Headache, dizziness
  • Blurred vision, retinopathy (long-term use)
  • Itching
  • Cardiac arrhythmias (rare)

Contraindication

  • Retinal or visual field changes
  • Known hypersensitivity to chloroquine
  • Psoriasis (risk of exacerbation)
  • Pregnancy (use with caution)

Interaction

  • Antiepileptic drugs (reduced efficacy)
  • Digoxin (increased levels)
  • Antacids (reduce absorption)
  • Other QT-prolonging drugs

Warning and Precautions

  • Use under medical supervision
  • Monitor vision regularly during long-term therapy
  • Monitor ECG in cardiac patients
  • Adjust dose in renal impairment

Dosage

As directed by the Physician.

Disclaimer

All product details on this website are for reference and informational purposes only and are not directed at patients or consumers.
As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
Please consult a healthcare professional before using any medicinal product.