'[:?. D M Pharma- Cefuroxime Axteil 250 mg|Third Party Medicines Manufacturing

Cefuroxime Tablets

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Therapeutic Indication

Respiratory tract infections (bronchitis, pneumonia)
Urinary tract infections
Skin and soft tissue infections
ENT infections (sinusitis, otitis media, tonsillitis)
Gonorrhea
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Cefuroxime

Tablet

Cefuroxime Axetil is a second-generation cephalosporin antibiotic used to treat a wide range of bacterial infections. It works by inhibiting bacterial cell wall synthesis, leading to bacterial cell death. It is effective in treating respiratory tract infections, urinary tract infections, skin infections, sinusitis, and ear infections.
Speciality Antibiotic | Cephalosporin
Tags Respiratory | UTI | Skin Infections | ENT | Gonorrhea
Strength
  • 250 mg
  • 500 mg
Packing Size
  • 10 Tablets

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Mechanism

Cefuroxime is a β-lactam type antibiotic. More specifically, it is a second-generation cephalosporin. Cephalosporins work the same way as penicillins: they interfere with the peptidoglycan synthesis of the bacterial wall by inhibiting the final transpeptidation needed for the cross-links. This effect is bactericidal. Cefuroxime is effective against the following organisms: Aerobic Gram-positive Microorganisms: Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes. Aerobic Gram-negative Microorganisms: Escherichia coli, Haemophilus influenzae (including beta-lactamase-producing strains), Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis (including beta-lactamase-producing strains), Neisseria gonorrhoeae (including beta-lactamase-producing strains). Spirochetes: Borrelia burgdorferi. Cefuroxime axetil is the prodrug.

Pharmacokinetics

  • Absorption: It is absorbed from the gastrointestinal tract. Absorption is greater when taken after food (absolute bioavailability increases from 37% to 52%).
  • Protein Binding: 50% to serum protein.
  • Metabolism: The axetil moiety is metabolized to acetaldehyde and acetic acid.
  • Half life: Its half life is Approximately 80 minutes following intramuscular or intravenous injection.

Side Effects

  • Nausea
  • Diarrhea
  • Abdominal pain
  • Allergic reactions (rare)

Contraindication

  • Hypersensitivity to cephalosporins
  • History of severe allergic reaction to penicillins

Interaction

  • Probenecid — increases plasma concentration of Cefuroxime
  • Antacids — may reduce absorption
  • Aminoglycosides — additive nephrotoxicity risk
  • Oral contraceptives — reduced efficacy due to altered gut flora

Warning and Precautions

  • Use under medical supervision in liver disease
  • Generally non-drowsy, but caution advised in sensitive individuals
  • Safe for long-term use as prescribed
  • Consult doctor during pregnancy and lactation