Cefixime + Sulbactam Tablets

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Therapeutic Indication

Tonsillitis
Pharyngitis
Otitismedia
Urinary tract infections
Gonorrhea
Infections caused by susceptible organisms
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Cefixime + Sulbactam

Tablet

Cefixime Trihydrate , an antibiotic, is a third-generation cephalosporin like ceftriaxone and cefotaxime. Cefixime is highly stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and some cephalosporins due to the presence of beta- lactamases, may be susceptible to cefixime. The antibacterial effect of cefixime results from inhibition of mucopeptide synthesis in the bacterial cell wall.

Speciality General Medicine
Tags Antibiotic | Cephalosporin
Strength
  • 50 mg
  • 100 mg
  • 200 mg
Packing Size
  • 10 Tablets

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Mechanism

Cefixime is an orally active 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefixime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefixime. It is highly active against enterobacteriaceae, Haemophilus influenzae, Streptococcus pyogens & Streptococcus pneumonia &many beta lactamase producing bacteria.

Pharmacokinetics

  • Absorption: Approximately 40–50% absorbed orally; food may delay absorption.
  • Distribution: Widely distributed in body tissues and fluids.
  • Metabolism: Partially metabolized.
  • Elimination: Primarily excreted via urine.
  • Half-life: Around 3–4 hours.

Side Effects

  • Diarrhea
  • Nausea
  • Abdominal pain
  • Flatulence
  • Indigestion

Contraindication

  • Hypersensitivity to cephalosporins
  • History of severe allergic reactions to beta-lactam antibiotics
  • Pseudomembranous colitis

Interaction

  • Probenecid: Increases cefixime concentration.
  • Oral anticoagulants: May enhance anticoagulant effects.
  • Carbamazepine: Increased serum levels may occur.

Warning and Precautions

This has been prescribed for the patient's specific condition. It may be dangerous to any other person.

  • Use with caution in renal impairment
  • Caution in patients with gastrointestinal disorders
  • Complete the full course of therapy
  • Avoid unnecessary use to prevent antibiotic resistance
  • Use in pregnancy and lactation under medical supervision