Calcium Orotate Tablets

Mechanism

Calcium Orotate provides bioavailable calcium for bone mineralization. Orotic acid acts as a carrier, enhancing calcium transport into cells and tissues, supporting bone strength and density.

Pharmacokinetics

• Absorption: Well absorbed orally; orotate form enhances cellular uptake.
• Bioavailability: Higher compared to carbonate and some other calcium salts.
• Distribution: Widely distributed to bones and teeth; supports mineralization.
• Metabolism: Orotic acid metabolized in the liver; calcium utilized in bone and muscle.
• Excretion: Calcium excreted via urine and feces; orotic acid metabolites via urine.
• Half-life: Calcium turnover depends on bone metabolism; orotic acid ~hours.

Side Effects

• Constipation
• Nausea
• Flatulence
• Hypercalcemia (rare)

Contraindication

• Hypercalcemia
• Renal calculi
• Hypersensitivity to calcium salts

Interaction

• Thiazide diuretics (increase calcium levels)
• Digitalis (risk of arrhythmias with hypercalcemia)
• Iron supplements (may reduce absorption)

Warning and Precautions

• Use under medical supervision only
• Monitor calcium levels during therapy
• Ensure adequate hydration