Calcium Citrate Malate + Vitamin D3 + Folic Acid Tablets

Mechanism

Calcium Citrate Malate provides bioavailable calcium for bone mineralization. Vitamin D3 enhances intestinal absorption of calcium and phosphate. Folic Acid supports DNA synthesis and red blood cell formation, especially important in pregnancy.

Pharmacokinetics

• Calcium Absorption: Citrate Malate form ensures high bioavailability and better absorption compared to carbonate.
• Vitamin D3 Absorption: Fat‑soluble; absorbed in the intestine and metabolized in the liver and kidneys to active calcitriol.
• Folic Acid Absorption: Rapidly absorbed in the small intestine; converted to active tetrahydrofolate.
• Distribution: Calcium distributed to bones and teeth; Vitamin D3 stored in fat and muscle; Folic Acid widely distributed in tissues.
• Excretion: Calcium via urine and feces; Vitamin D3 metabolites via bile; Folic Acid via urine.
• Half-life: Calcium ~hours; Vitamin D3 ~15 days; Folic Acid ~3–4 hours.

Side Effects

• Constipation
• Flatulence
• Nausea
• Hypercalcemia (rare)

Contraindication

• Hypercalcemia
• Renal calculi
• Hypersensitivity to any component

Interaction

• Thiazide diuretics (increase calcium levels)
• Anticonvulsants (reduce Vitamin D3 efficacy)
• Methotrexate (interacts with folic acid)

Warning and Precautions

• Use under medical supervision only
• Monitor calcium levels in long‑term therapy
• Ensure adequate hydration

Dosage

As directed by the Physician.