Ipriflavone, Alfacalcidol with Calcium Carbonate Tablets

Mechanism

Calcium Citrate provides bioavailable calcium; Ipriflavone supports bone formation and reduces resorption; Calcitriol regulates calcium absorption and bone metabolism; Vitamin D3 enhances calcium uptake and bone mineralization.

Pharmacokinetics

• Absorption: Calcium absorbed in intestine; Alfacalcidol rapidly absorbed orally.
• Distribution: Calcium distributed to bone and extracellular fluid; Alfacalcidol binds plasma proteins.
• Metabolism: Alfacalcidol converted in liver to active calcitriol; Ipriflavone metabolized hepatically.
• Elimination: Calcium excreted via urine and feces; metabolites via bile.
• Half-life: Alfacalcidol ~3–6 hrs; Calcium varies with intake.

Side Effects

• Mild gastrointestinal discomfort
• Hypercalcemia (rare)
• Allergic reactions

Contraindication

• Hypercalcemia
• Renal calculi
• Hypersensitivity to any component

Interaction

• Use cautiously with bisphosphonates — medical supervision required
• Corticosteroids may reduce calcium absorption
• Risk of hypercalcemia when combined with cardiac glycosides
• Monitor when taken with other Vitamin D supplements

Warning and Precautions

• Monitor serum calcium and vitamin D levels during therapy.
• Use with caution in patients with renal impairment.
• Not recommended for long-term unsupervised use.

Dosage

As directed by the Physician.