Calcium Citrate Malate + Calcitriol + Vitamin K2-7 Tablets

Mechanism

Calcium Citrate Malate: Provides bioavailable calcium for bone mineralization.
Vitamin K2-7: Directs calcium to bones and prevents deposition in arteries.
Calcitriol: Active form of Vitamin D3, enhances calcium absorption in the intestine and regulates bone metabolism.

Pharmacokinetics

• Calcium Absorption: Citrate Malate form ensures high bioavailability and better absorption compared to carbonate.
• Calcitriol Absorption: Rapidly absorbed; peak plasma concentration within 3–6 hours.
• Vitamin k2-7 Absorption: Fat‑soluble; absorbed in intestine and metabolized to calcitriol.
• Distribution: Calcium distributed to bones and teeth; Calcitriol and Vitamin D3 stored in fat and muscle.
• Excretion: Calcium via urine and feces; Vitamin D metabolites via bile; Calcitriol via urine.
• Half-life: Calcium ~hours; Vitamin D3 ~15 days; Calcitriol ~5–8 hours.

Side Effects

• Mild gastrointestinal upset
• Constipation (due to calcium)
• Hypercalcemia (high doses)
• Rare allergic reactions

Contraindication

• Hypersensitivity to any component
• Hypercalcemia or hypervitaminosis D
• Severe renal impairment
• Patients with vascular calcification (use cautiously)

Interaction

• Calcium may reduce absorption of tetracycline & fluoroquinolone antibiotics
• Calcitriol may interact with corticosteroids (reduces efficacy)
• Vitamin K2 may interfere with anticoagulant therapy (warfarin)

Warning and Precautions

• Do not exceed recommended daily dose
• Monitor calcium levels during long-term use
• Use cautiously in patients with kidney stones
• Consult physician before combining with other supplements or medications

Dosage

As directed by the Physician.