Bilastine Tablets

Mechanism

Bilastine selectively blocks histamine H1 receptors, preventing histamine from binding and triggering allergic symptoms. It reduces sneezing, itching, nasal congestion, and skin reactions without crossing the blood-brain barrier, minimizing sedation.

Pharmacokinetics

• Absorption: Rapid oral absorption; bioavailability ~60%.
• Distribution: Widely distributed; minimal CNS penetration.
• Metabolism: Minimal hepatic metabolism.
• Elimination: Excreted mainly unchanged in urine and feces.
• Half-life: ~14 hours.

Side Effects

• Headache
• Abdominal pain
• Dizziness
• Fatigue

Contraindication

• Hypersensitivity to Bilastine
• Children under 12 years (safety not established)
• Pregnancy and lactation (use with caution)

Interaction

• Alcohol (may increase drowsiness)
• Ketoconazole, erythromycin (increase plasma levels)
• Other sedating antihistamines (additive effect)

Warning and Precautions

• Use under medical supervision only
• Avoid driving if dizziness occurs
• Stop at least 3 days before allergy testing

Dosage

As directed by the Physician.