Betahistine Tablets

Mechanism

Betahistine acts as a histamine analogue. It primarily acts as an H1 receptor agonist and H3 receptor antagonist, leading to vasodilation in the inner ear and improved vestibular function. This reduces endolymphatic pressure and improves symptoms of vertigo.

Pharmacokinetics

• Absorption: Rapid and complete after oral administration
• Distribution: Low plasma protein binding
• Metabolism: Converted to inactive metabolite (2-pyridylacetic acid)
• Elimination: Primarily excreted in urine

Side Effects

• Headache
• Nausea
• Indigestion
• Gastric discomfort

Contraindication

• Pheochromocytoma
• Hypersensitivity to Betahistine

Interaction

• Antihistamines (may reduce effectiveness)
• MAO inhibitors (increase betahistine levels)

Warning and Precautions

This has been prescribed for the patient's specific condition. It may be dangerous to any other person.

• Use cautiously in bronchial asthma
• Use carefully in peptic ulcer patients
• Consult physician during pregnancy and lactation