Beta-Carotene + Alfacalcidol + Calcium Carbonate Tablets

Mechanism

Beta-Carotene:

• Acts as a precursor to Vitamin A (retinol), supporting vision, epithelial integrity, and immune function.
• Functions as a potent antioxidant, neutralizing free radicals and reducing oxidative stress.
• Regulates gene expression related to cell differentiation and growth.

Alfacalcidol:

• A synthetic analogue of Vitamin D3, rapidly converted in the liver to calcitriol (active form).
• Enhances intestinal absorption of calcium and phosphate, promoting bone mineralization.
• Regulates parathyroid hormone secretion, reducing bone resorption.
• Supports neuromuscular function and immune modulation.

Calcium Carbonate:

• Provides elemental calcium, essential for bone strength and density.
• Neutralizes gastric acid, aiding in calcium absorption.
• Supports muscle contraction, nerve transmission, and blood clotting.

Pharmacokinetics

• Absorption: Beta-Carotene absorbed in intestine with dietary fat; Alfacalcidol absorbed rapidly; Calcium Carbonate requires acidic medium for optimal absorption.
• Distribution: Beta-Carotene stored in liver and adipose tissue; Alfacalcidol distributed systemically; Calcium incorporated into bone and extracellular fluid.
• Metabolism: Beta-Carotene converted to retinol; Alfacalcidol hydroxylated in liver to calcitriol; Calcium undergoes minimal metabolism.
• Elimination: Beta-Carotene via bile; Alfacalcidol metabolites via urine; Calcium excreted via urine and feces.

Side Effects

• Beta-Carotene: Carotenemia (orange skin discoloration), GI upset
• Alfacalcidol: Hypercalcemia, headache, nausea
• Calcium Carbonate: Constipation, bloating, kidney stones (long-term high dose)

Contraindication

• Hypersensitivity to any component
• Hypercalcemia or hypervitaminosis D
• Severe renal impairment

Interaction

• Beta-Carotene absorption reduced by alcohol and smoking
• Alfacalcidol interacts with thiazide diuretics, digoxin
• Calcium Carbonate reduces absorption of tetracyclines, bisphosphonates, levothyroxine

Warning and Precautions

• Monitor serum calcium and vitamin D levels during therapy.
• Use cautiously in patients with renal impairment or kidney stones.
• Long-term use requires periodic bone density evaluation.
• Pregnant and lactating women should use only under medical advice.
• Store in a cool, dry place away from sunlight.

Dosage

As directed by the Physician.