Benidipine Tablets

Therapeutic Indication

Hypertension (high blood pressure)

Stable and variant angina pectoris

Cardiovascular protection in hypertensive patients

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Benidipine

Tablet

Benidipine is a long-acting calcium channel blocker (CCB) that inhibits L-, T-, and N-type calcium channels. It is effective in lowering blood pressure, improving coronary blood flow, and reducing cardiac workload. Benidipine is widely prescribed for hypertension and angina, offering dual cardiovascular benefits.

Speciality	Calcium Channel Blocker (CCB)
Tags	Antihypertensive \| Angina \| Calcium Channel Blocker
Strength	4 mg 8 mg
Packing Size	10 Tablets

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Mechanism

Benidipine blocks L-, T-, and N-type calcium channels in vascular smooth muscle and cardiac tissue. This reduces calcium influx, leading to vasodilation, decreased peripheral resistance, and improved coronary blood flow.

Pharmacokinetics

Absorption: Well absorbed orally
Distribution: Widely distributed in vascular tissues
Metabolism: Hepatic metabolism via CYP3A4
Elimination: Primarily fecal excretion
Half-life: 8–10 hours

Side Effects

Dizziness
Headache
Peripheral edema
Flushing
Rare gingival hyperplasia

Contraindication

Severe hypotension
Cardiogenic shock
Hypersensitivity to Benidipine

Interaction

CYP3A4 inhibitors (increase Benidipine levels)
CYP3A4 inducers (reduce Benidipine efficacy)
Other antihypertensives (additive blood pressure lowering)

Warning and Precautions

Monitor blood pressure regularly
Use cautiously in patients with hepatic impairment
Adjust dose in elderly patients