Aripiprazole Tablets

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Therapeutic Indication

Schizophrenia
Bipolar I disorder (manic/mixed episodes)
Adjunctive treatment of major depressive disorder
Irritability associated with autistic disorder
Tourette’s disorder
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Aripiprazole

Tablet

Aripiprazole is an atypical antipsychotic medication mainly used to treat serious mental health conditions. It works by balancing specific neurotransmitters in the brain, like dopamine and serotonin, to improve mood, thoughts, and behaviors.

Speciality Psychiatry
Tags Atypical Antipsychotic | Dopamine Partial Agonist
Strength
  • 5 mg
  • 10 mg
  • 15 mg
  • 20 mg
  • 30 mg
Packing Size
  • 10 Tablets

Check all Tablets Range

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Mechanism

Aripiprazole acts as a partial agonist at dopamine D2 and serotonin 5‑HT1A receptors, and as an antagonist at serotonin 5‑HT2A receptors. This unique mechanism stabilizes dopamine and serotonin activity, reducing psychotic symptoms while minimizing extrapyramidal side effects.

Pharmacokinetics

  • Absorption: Oral bioavailability ~87%; peak plasma levels in 3–5 hrs.
  • Distribution: Widely distributed; ~99% plasma protein bound.
  • Metabolism: Hepatic via CYP2D6 & CYP3A4; active metabolite dehydro-aripiprazole contributes ~40% exposure.
  • Excretion: Excreted via urine (~25%) and feces (~55%).
  • Half-life: Aripiprazole ~75 hrs; metabolite ~94 hrs.

Side Effects

  • Headache
  • Insomnia
  • Anxiety
  • Nausea, vomiting
  • Weight gain, metabolic changes
  • Rare: Tardive dyskinesia, neuroleptic malignant syndrome

Contraindication

  • Hypersensitivity to Aripiprazole
  • Elderly patients with dementia-related psychosis (↑ mortality risk)

Interaction

  • CYP3A4 inhibitors (e.g., ketoconazole) ↑ Aripiprazole levels
  • CYP3A4 inducers (e.g., carbamazepine) ↓ Aripiprazole levels
  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine) ↑ Aripiprazole levels

Warning and Precautions

  • Boxed warning: ↑ risk of suicidal thoughts in children, adolescents, and young adults
  • Monitor metabolic parameters (weight, glucose, lipids)
  • Use cautiously in patients with cardiovascular disease

Dosage

As directed by the Physician.

Disclaimer

All product details on this website are for reference and informational purposes only and are not directed at patients or consumers.
As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
Please consult a healthcare professional before using any medicinal product.