Amitriptyline + Chlordiazepoxide Tablets

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Therapeutic Indication

Depression with Anxiety
Generalized Anxiety Disorder
Mixed Anxiety-Depressive States
Psychosomatic Disorders
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Amitriptyline + Chlordiazepoxide

Tablet

This combination pairs Amitriptyline, a tricyclic antidepressant, with Chlordiazepoxide, a benzodiazepine anxiolytic. Together, they help manage depression accompanied by anxiety, psychosomatic disorders, and related conditions.

Speciality Psychiatry | Neurology
Tags Depression | Anxiety | Psychosomatic Disorders
Strength
  • Amitriptyline 12.5 mg
  • Chlordiazepoxide 5 mg
Packing Size
  • 10 Tablets

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Mechanism

Amitriptyline inhibits reuptake of serotonin and norepinephrine, enhancing mood. Chlordiazepoxide potentiates GABA activity, producing anxiolytic and sedative effects.

Pharmacokinetics

  • Absorption: Well absorbed orally.
  • Distribution: Amitriptyline highly protein bound; Chlordiazepoxide widely distributed.
  • Metabolism: Amitriptyline via CYP2D6; Chlordiazepoxide metabolized hepatically to active metabolites.
  • Excretion: Primarily via urine.
  • Half-life: Amitriptyline ~15–40 hrs; Chlordiazepoxide ~5–30 hrs.

Side Effects

  • Drowsiness
  • Dry mouth
  • Constipation
  • Weight gain
  • Dizziness
  • Risk of dependence (Chlordiazepoxide)

Contraindication

  • Hypersensitivity to either component
  • Severe liver impairment
  • History of substance abuse
  • Concurrent MAOI therapy

Interaction

  • Alcohol and sedatives (enhanced CNS depression)
  • MAOIs (risk of serotonin syndrome)
  • SSRIs (additive serotonergic effects)
  • Antihypertensives (potentiated hypotension)

Warning and Precautions

  • Monitor for sedation and psychomotor impairment.
  • Risk of dependence and withdrawal with long-term use of Chlordiazepoxide.
  • Use cautiously in elderly patients due to fall risk.
  • May cause anticholinergic side effects (blurred vision, urinary retention).
  • Gradual tapering recommended to avoid withdrawal symptoms.
  • Regular monitoring of liver function and mental status advised.

Dosage

As directed by the Dietician.

Disclaimer

All product details on this website are for reference and informational purposes only and are not directed at patients or consumers.
As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
Please consult a healthcare professional before using any medicinal product.