Alfuzosin Tablets | DM Pharma

Therapeutic Indication

Benign prostatic hyperplasia (BPH)

Relief of lower urinary tract symptoms (LUTS)

Improved urinary flow and bladder emptying

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Alfuzosin

Tablet

Alfuzosin is an alpha-1 adrenergic receptor blocker used in the management of benign prostatic hyperplasia (BPH). It relaxes smooth muscle in the prostate and bladder neck, improving urinary flow and reducing symptoms of obstruction. Alfuzosin is prescribed to relieve lower urinary tract symptoms associated with BPH.

Speciality	Urology / Alpha-1 Blocker
Tags	BPH \| Urinary Symptoms \| Alpha-1 Blocker
Strength	10 mg
Packing Size	10 Tablets

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Mechanism

Alfuzosin selectively blocks alpha-1 adrenergic receptors in the prostate and bladder neck. This reduces smooth muscle tone, decreases resistance to urinary flow, and improves bladder emptying in patients with BPH.

Pharmacokinetics

Absorption: Oral absorption enhanced with food
Distribution: Highly protein bound
Metabolism: Hepatic metabolism via CYP3A4
Elimination: Fecal and renal excretion
Half-life: ≈ 10 hours (extended-release formulation)

Side Effects

Dizziness
Headache
Fatigue
Postural hypotension
Rare: syncope

Contraindication

Severe hepatic impairment
Hypersensitivity to Alfuzosin

Interaction

CYP3A4 inhibitors (ketoconazole, ritonavir) — increase plasma levels
Antihypertensives — additive hypotensive effect
Nitrates — risk of severe hypotension
Other alpha-blockers — enhanced risk of orthostatic hypotension

Warning and Precautions

Monitor blood pressure regularly
Use cautiously in elderly patients
Advise patients to avoid sudden posture changes (risk of dizziness)