Alendronate Tablets

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Therapeutic Indication

Postmenopausal osteoporosis – prevention and treatment
Osteoporosis in men
Glucocorticoid-induced osteoporosis
Paget’s disease of bone
Prevention of fractures in high-risk patients
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Alendronate

Tablet

Alendronate is a bisphosphonate medication used to prevent and treat osteoporosis in postmenopausal women and men, and to manage Paget’s disease of bone. It works by inhibiting bone resorption, thereby increasing bone mineral density.

Speciality Orthopedics | Endocrinology | Rheumatology
Tags Osteoporosis | Paget’s Disease | Bisphosphonate | Bone Resorption Inhibitor
Strength
  • 70 mg
Packing Size
  • 10 Tablets

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Mechanism

Alendronate binds strongly to hydroxyapatite in bone and inhibits osteoclast-mediated bone resorption. It interferes with the mevalonate pathway, leading to osteoclast apoptosis and reduced bone turnover.

Pharmacokinetics

  • Absorption: Poor oral bioavailability (~0.6%)
  • Distribution: Rapidly taken up by bone
  • Metabolism: Not metabolized
  • Excretion: Renal excretion unchanged
  • Half-life: >10 years in bone

Side Effects

  • Esophageal irritation, dyspepsia, abdominal pain
  • Musculoskeletal pain
  • Hypocalcemia
  • Rare: Osteonecrosis of the jaw, atypical femoral fractures

Contraindication

  • Esophageal abnormalities (e.g., stricture, achalasia)
  • Inability to stand or sit upright for 30 minutes
  • Hypocalcemia
  • Severe renal impairment (CrCl <35 mL/min)

Interaction

  • Calcium supplements, antacids, iron: Reduce absorption if taken together.
  • NSAIDs: Increase risk of GI irritation.
  • Aminoglycosides: May increase risk of hypocalcemia.

Warning and Precautions

  • Ensure adequate calcium and vitamin D intake.
  • Monitor renal function and serum calcium.
  • Discontinue if severe bone, joint, or muscle pain occurs.

Safe Administration Guidance

After administration of the tablet, take with a full glass of water and remain upright for at least 30 minutes. This ensures proper passage of the medicine into the stomach and reduces the risk of esophageal irritation.

Dosage

As directed by the Physician.

Disclaimer

All product details on this website are for reference and informational purposes only and are not directed at patients or consumers.
As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
Please consult a healthcare professional before using any medicinal product.