Albendazole + Ivermectin Tablets

Project Image
Thumb Image

Therapeutic Indication

Intestinal helminth infections (roundworm, hookworm, whipworm, pinworm)
Strongyloidiasis
Filariasis
Mixed parasitic infections
Adjunct therapy in endemic deworming programs
+91 85919 78885

Albendazole + Ivermectin

Tablet

This fixed-dose combination provides broad-spectrum antiparasitic activity. Albendazole disrupts parasite metabolism, while Ivermectin paralyzes and kills worms by acting on neuromuscular transmission. Together, they are effective against intestinal worms, filarial infections, and mixed parasitic infestations.

Speciality Anthelmintic | Anti-parasitic
Tags Deworming | Anthelmintic | Filariasis | Strongyloidiasis | Mixed Infections
Strength
  • Albendazole 400 mg
  • Ivermectin 6 mg/12 mg
Packing Size
  • 1 Tablets

Check all Tablet Range

Click to know More

Mechanism

Albendazole: Binds to parasite β‑tubulin, inhibiting microtubule polymerization, disrupting glucose uptake, and leading to parasite death. Ivermectin: Binds to glutamate-gated chloride channels in parasite nerve and muscle cells, causing paralysis and death.

Pharmacokinetics

  • Absorption: Albendazole has poor oral absorption, enhanced with fatty meals; Ivermectin is well absorbed orally.
  • Distribution: Albendazole sulfoxide penetrates CSF; Ivermectin distributes widely but does not cross BBB significantly.
  • Metabolism: Albendazole rapidly metabolized in liver to active sulfoxide; Ivermectin metabolized hepatically.
  • Elimination: Albendazole metabolites excreted in urine; Ivermectin mainly via feces.
  • Half-life: Albendazole sulfoxide ≈ 8–12 hours; Ivermectin ≈ 12–36 hours.

Side Effects

  • Nausea, vomiting
  • Abdominal pain
  • Dizziness, headache
  • Skin rash, pruritus
  • Rare: elevated liver enzymes, bone marrow suppression

Contraindication

  • Hypersensitivity to Albendazole, Ivermectin, or excipients
  • Pregnancy (especially first trimester)
  • Severe hepatic impairment
  • Children under 2 years (safety not established)

Interaction

  • Cimetidine, Praziquantel, Dexamethasone: Increase Albendazole sulfoxide levels.
  • Hepatotoxic drugs: Additive risk of liver injury.
  • Other antiparasitics: Possible additive effects.

Warning and Precautions

  • Monitor liver function during prolonged therapy.
  • Use effective contraception during and after treatment (in women of childbearing age).
  • Discontinue if severe hypersensitivity or bone marrow suppression occurs.
  • Use cautiously in endemic mass deworming programs.