Aceclofenac SR Tablets

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Therapeutic Indication

Osteoarthritis and rheumatoid arthritis
Musculoskeletal pain and stiffness
Post-surgical pain and swelling
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Aceclofenac SR

Tablet

Aceclofenac Sustained Release tablets are designed to release the drug slowly over time, ensuring prolonged pain relief and improved patient compliance. They are commonly prescribed for arthritis and chronic musculoskeletal conditions requiring long-term therapy.

Speciality Orthopedics | Rheumatology | Pain Management
Tags NSAID | Sustained Release | Anti-inflammatory | Pain Relief
Strength
  • SR 200 mg
Packing Size
  • 10 Tablets

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Mechanism

Aceclofenac inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis → decreases inflammation, pain, and swelling. The sustained release formulation ensures steady plasma levels, prolonged action, and improved compliance.

Pharmacokinetics

  • Absorption: Rapid oral absorption; sustained release formulation prolongs effect.
  • Distribution:Highly protein bound (~99%).
  • Metabolism: active metabolite diclofenac.
  • Elimination: Renal and biliary excretion.
  • Half-life: 4–5 hours (extended in sustained release).

Side Effects

  • Gastric irritation, nausea, dyspepsia
  • Dizziness, headache
  • Rare: liver toxicity
  • Prolonged use may increase risk of GI bleeding

Contraindication

  • Severe liver or kidney disease
  • History of gastric ulcers or GI bleeding
  • Pregnancy & breastfeeding (use with caution)
  • Hypersensitivity to NSAIDs

Interaction

  • Alcohol: Increases risk of gastric bleeding and liver damage.
  • Anticoagulants: May enhance bleeding risk.
  • Other NSAIDs: Avoid duplication of therapy.
  • Hepatotoxic drugs: Increased risk of liver injury.

Warning and Precautions

  • Do not exceed recommended dose.
  • Monitor liver function during prolonged use.
  • Use cautiously in patients with GI disorders.
  • Discontinue if severe allergic reaction occurs.
  • SR formulation should not be crushed or chewed.

Dosage

As directed by the Physician.