Aceclofenac + Paracetamol Tablets

Project Image
Thumb Image
Thumb Image

Therapeutic Indication

Musculoskeletal pain (back, neck, shoulder)
Inflammation and swelling due to injury
Fever reduction in infections
Arthritis and joint stiffness
Post-surgical pain and inflammation
Dental pain and headache
+91 85919 78885

Aceclofenac + Paracetamol

Tablet

This dual-action combination provides enhanced relief: Aceclofenac reduces inflammation and pain, while Paracetamol lowers fever and boosts analgesic effect. It is widely prescribed for acute musculoskeletal conditions, arthritis, and post-operative recovery.

Speciality Orthopedics | Rheumatology | Pain Management
Tags NSAID | Analgesic | Antipyretic | Combination Therapy
Strength
  • Aceclofenac 100 mg
  • Paracetamol 325 mg
Packing Size
  • 10 Tablets

Check all Tablet Range

Click to know More

Mechanism

Aceclofenac: Inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis → decreases inflammation, pain, and swelling.
Paracetamol: Acts centrally on the hypothalamus to reduce fever and modulates pain pathways → enhances analgesic effect.

Pharmacokinetics

  • Absorption: Rapid oral absorption for both drugs.
  • Distribution: Aceclofenac widely distributed in tissues; Paracetamol crosses blood-brain barrier.
  • Metabolism: Aceclofenac metabolized hepatically; Paracetamol undergoes glucuronidation, sulfation, and minor CYP-mediated oxidation.
  • Elimination: Renal and fecal excretion.
  • Half-life: Aceclofenac ~4 hrs; Paracetamol ~2–3 hrs.

Side Effects

  • Gastric irritation, nausea, dyspepsia
  • Dizziness, headache
  • Rare: liver toxicity (especially with overdose)
  • Allergic reactions (rash, itching)
  • Prolonged use may increase risk of GI bleeding

Contraindication

  • Severe liver or kidney disease
  • History of gastric ulcers or GI bleeding
  • Pregnancy & breastfeeding (use with caution)
  • Hypersensitivity to NSAIDs or Paracetamol

Interaction

  • Alcohol: Increases risk of gastric bleeding and liver damage.
  • Anticoagulants: Aceclofenac and Paracetamol may enhance bleeding risk.
  • Other NSAIDs: Avoid duplication of therapy.
  • Hepatotoxic drugs: Increased risk of liver injury with Paracetamol.
  • CYP inducers: May alter metabolism of Paracetamol.

Warning and Precautions

  • Do not exceed recommended dose.
  • Monitor liver function during prolonged use.

Dosage

As directed by the Physician.