Aceclofenac + Drotaverine Tablets

Therapeutic Indication

Musculoskeletal pain

Inflammation and swelling

Abdominal cramps and smooth muscle spasms

Arthritis and joint pain

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Aceclofenac + Drotaverine

Tablet

This combination medicine provides dual relief: Aceclofenac reduces inflammation and pain, while Drotaverine relaxes smooth muscles to relieve spasms. It is prescribed for musculoskeletal pain, abdominal cramps, and arthritis-related discomfort.

Speciality	Orthopedics \| Pain Management \| Gastroenterology
Tags	NSAID \| Antispasmodic \| Pain Relief
Strength	Aceclofenac 100 mg Drotaverine 80 mg
Packing Size	10 Tablets

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Mechanism

Aceclofenac inhibits prostaglandin synthesis, reducing inflammation and pain. Drotaverine inhibits phosphodiesterase-IV, increasing cAMP levels in smooth muscle cells, leading to relaxation and spasm relief.

Pharmacokinetics

Absorption: Rapid oral absorption.
Distribution: Widely distributed.
Metabolism: Hepatic metabolism.
Elimination: Renal and fecal excretion.
Half-life: Aceclofenac ~4 hrs; Drotaverine ~7–9 hrs.

Side Effects

Gastric irritation, nausea
Dizziness, headache
Rare: liver toxicity

Contraindication

Severe liver or kidney disease
History of gastric ulcers
Pregnancy & breastfeeding (use with caution)
Hypersensitivity to NSAIDs or Drotaverine

Interaction

Alcohol: Increases risk of gastric bleeding and liver damage.
Anticoagulants: Aceclofenac may enhance bleeding risk.
Other NSAIDs: Avoid duplication of therapy.

Warning and Precautions

Do not exceed recommended dose.
Use cautiously in patients with GI disorders.
Monitor liver function during prolonged use.

Dosage

As directed by the Physician.