Aceclofenac + Diacerein Tablets

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Therapeutic Indication

Osteoarthritis management
Musculoskeletal pain
Inflammation and swelling
Joint stiffness
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Aceclofenac + Diacerein

Tablet

This combination medicine is widely prescribed for osteoarthritis and chronic joint pain. Aceclofenac reduces inflammation and pain, while Diacerein slows cartilage degeneration and improves joint function.

Speciality Orthopedics | Rheumatology | Pain Management
Tags NSAID | Disease-modifying | Osteoarthritis Therapy
Strength
  • Aceclofenac 100 mg
  • Diacerein 50 mg
Packing Size
  • 10 Tablets

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Mechanism

Aceclofenac inhibits prostaglandin synthesis, reducing inflammation and pain. Diacerein modulates interleukin-1 activity, slowing cartilage breakdown and promoting joint repair.

Pharmacokinetics

  • Absorption: Rapid oral absorption.
  • Distribution: Widely distributed in tissues.
  • Metabolism: Hepatic metabolism.
  • Elimination: Renal and fecal excretion.
  • Half-life: Aceclofenac ~4 hrs; Diacerein ~6–8 hrs.

Side Effects

  • Gastric irritation, nausea
  • Diarrhea (common with Diacerein)
  • Dizziness, headache
  • Rare: liver toxicity

Contraindication

  • Severe liver or kidney disease
  • History of gastric ulcers
  • Pregnancy & breastfeeding
  • Hypersensitivity to NSAIDs or Diacerein

Interaction

  • Alcohol: Increases risk of gastric bleeding and liver damage.
  • Anticoagulants: Aceclofenac may enhance bleeding risk.
  • Other NSAIDs: Avoid duplication of therapy.

Warning and Precautions

  • Do not exceed recommended dose.
  • Monitor liver function during prolonged use.
  • Use cautiously in patients with GI disorders.
  • Diacerein may cause loose stools; dose adjustment may be needed.

Dosage

As directed by the Physician.