Acamprosate Calcium Tablets

Therapeutic Indication

Maintenance of abstinence in alcohol dependence

Supportive therapy with counseling and psychosocial support

Acamprosate Calcium

Tablet

Acamprosate helps restore the balance of neurotransmitters disrupted by chronic alcohol use, reducing cravings and relapse risk.

Speciality	Psychiatry \| Addiction Medicine \| General Medicine
Tags	Alcohol dependence \| Relapse prevention \| Supportive therapy
Strength	333 mg
Packing Size	10 Tablets

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Mechanism

Acamprosate modulates glutamate and GABA neurotransmission, helping restore balance disrupted by alcohol dependence.

Pharmacokinetics

Absorption: Poor oral bioavailability (~11%).
Distribution: Minimal protein binding.
Metabolism: Not metabolized by liver.
Elimination: Excreted unchanged in urine.
Half-life: ~20–33 hours.

Side Effects

Diarrhea
Nausea, flatulence
Depression, anxiety
Skin rash

Contraindication

Hypersensitivity to Acamprosate
Severe renal impairment (CrCl ≤30 mL/min)

Interaction

No major drug interactions reported
Safe with benzodiazepines and antidepressants

Warning and Precautions

Use only under medical supervision
Monitor for depression or suicidality
Not effective unless patient is abstinent before starting

Dosage

As directed by the Physician.

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