Voriconazole Tablets

Therapeutic Indication

Invasive aspergillosis

Serious Candida infections

Esophageal candidiasis

Other severe fungal infections

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Voriconazole

Tablet

Voriconazole is a broad-spectrum triazole antifungal agent used in the treatment of serious and life-threatening fungal infections. It is highly effective against Aspergillus and Candida species and is commonly used in immunocompromised patients.

Speciality	Antifungal (Triazole Class)
Tags	Antifungal \| Infection Control \| Broad Spectrum
Strength	50 mg 200 mg
Packing Size	10 Tablets

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Mechanism

Voriconazole inhibits fungal cytochrome P450 enzyme (14-alpha-demethylase), which is essential for ergosterol synthesis. This disruption leads to impaired fungal cell membrane formation and ultimately fungal cell death.

Pharmacokinetics

Absorption: Well absorbed orally
Metabolism: Hepatic (CYP2C19, CYP2C9, CYP3A4)
Elimination: Primarily via metabolism

Side Effects

Visual disturbances
Headache
Nausea
Skin rash
Elevated liver enzymes

Contraindication

Hypersensitivity to Voriconazole
Concomitant use with certain CYP3A4 substrates
Severe liver dysfunction (caution)

Interaction

Rifampicin
Carbamazepine
Cyclosporine
Warfarin

Warning and Precautions

Monitor liver function
Visual disturbances may occur
Avoid excessive sunlight (photosensitivity)
Use under strict medical supervision

Dosage

As directed by the Physician.

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