Vitamin K2-7 + Methylcobalamin + Cholecalciferol + Calcium Citrate Tablets

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Therapeutic Indication

Beneficial in osteoporosis
Beneficial in rickets
Beneficial in osteomalacia
Maintain calcium level in body
Beneficial in bone health
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Vitamin K2-7 + Methylcobalamin + Cholecalciferol + Calcium Citrate

Tablet

This combination is useful in people having low blood calcium levels; who do not get enough calcium from their diets. Calcium is necessary for many normal functions of body, especially bone formation and maintenance. Low blood levels of calcium may cause bone disease. Thus this combination helps in maintance of calcium & healthy bones.
Calcium Citrate is calcium salt of citric acid. Calcium salt can be used in the prevention of calcium deficiency states. It is also used as an adjunct in the prevention of osteoporosis.
Methylcobalamin is the neurologically active form of the vitamin B12 and has strong effect on the brain and nervous system being also very important for cell growth and production. Methylcobalamin is used in variety of processes, including: production of red and white blood cell, the regeneration of RNA and DNA, synthesis of proteins. It is useful in vitamin B12 deficiency, psoriasis, pernicious anemia & atopic dermatitis.
Cholecalciferol is a fat soluble vitamin D3. Vitamin D is important for the absorption of calcium and phosphorus. Having the right amount of vitamin D, calcium, and phosphorus is important for building and keeping strong bones.
Vitamin K2-7 shown to have significant importance for optimal utilization of calcium in the body related to bone and cardiovascular health. Daily supplementation is expected to be beneficial for the bone building process as well as for cardiovascular health. Different forms of vitamin K2 are well documented and shown to be safe in numerous humans studies.

Speciality Bone Health | Osteoporosis Prevention | Neuropathy | Cardiovascular Support | Nutritional Deficiency
Tags Bone Strength | Nerve Regeneration | Immunity Booster
Strength
  • Vitamin K2-7 50 mcg
  • Methylcobalamin 1500 mcg
  • Cholecalciferol (Vitamin D3) 2000 IU
  • Calcium Citrate Malate 750 mg
Packing Size
  • 10 Tablets

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Mechanism

Calcium citrate: All of the calcium salts act as dietary supplements to prevent or treat negative calcium balance. Calcium citrate contains 21% elemental calcium.Absorption from the GI tract requires Vitamin D. Available elemental calcium depends on the salt form used, dose administered and the presence of an acid environment in the stomach. Elimination is primarily in the feces as unabsorbed calcium and the kidneys eliminate 20%.
Methylcobalamin: Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. By depleting excess homocystine, folate benefits cardiovascular health and nervous system function.
Cholecalciferol: Cholecalciferol (vitamin D3) is formed in the skin following exposure to ultraviolet light and it is taken in through food (e.g. fatty fish, dairy products). The vitamin is tranformed into active 1.25-dihydroxycholecalciferol (1.25(OH)2D3, calcitriol) in two hydroxylation steps, first in the liver, then in the kidneys. Calcitriol is a highly efficient steroid hormone. It regulates the metabolism of calcium and phospahtes by stimulating their intestinal absorption, the mobilisation from the bones, and the renal reabsorption of calcium.
Vitamin K2-7: Vitamin K2 is further of two types; The two subtypes most studied are menaquinone-4 (menatetrenone, MK-4) and menaquinone-7 (MK-7). Menaquinone-7 (MK-7) is different from MK-4 in that it is not produced by human tissue. MK-7 consumption has been shown to reduce the risk of bone fractures and cardiovascular disorders that are crucial health issues worldwide.

Pharmacokinetics

  • Absorption: Rapid intestinal absorption; peak plasma ~1.3 hrs.
  • Distribution: Protein bound ~56%; folate crosses blood-brain barrier.
  • Metabolism: Active forms bypass conversion; processed mainly in liver.
  • Elimination: Primarily renal excretion; half-life ~3 hrs.

Side Effects

  • Mild nausea, headache, or stomach upset may occur.
  • Use cautiously in patients with kidney or liver impairment.
  • Not recommended with anticoagulants (Vitamin K2 may interfere).

Contraindication

  • Hypersensitivity to any component of the formulation.
  • Patients with hypercalcemia or calcium metabolism disorders.
  • Severe renal impairment or nephrolithiasis (kidney stones).
  • Hemochromatosis or other iron overload conditions (due to folate/B12 interactions).

Interaction

  • Anticoagulants (Warfarin, Heparin): Vitamin K2 may reduce effectiveness.
  • Antacids & Proton Pump Inhibitors: May reduce calcium absorption.
  • Tetracycline & Quinolone Antibiotics: Calcium may interfere with absorption.
  • Phenytoin & Phenobarbital: May reduce Vitamin D3 effectiveness.
  • Alcohol (chronic use): May impair folate and B12 metabolism.

Warning and Precautions

  • Use under medical supervision, especially in patients with osteoporosis or cardiovascular disease.
  • Monitor serum calcium and Vitamin D levels during long-term therapy to avoid hypercalcemia.
  • Patients with renal impairment should use calcium supplements cautiously to prevent kidney stone formation.
  • Vitamin K2 may interfere with anticoagulant therapy; monitor INR levels closely if on warfarin or similar drugs.
  • Excessive Vitamin D3 intake may cause toxicity; avoid prolonged high-dose use without physician guidance.
  • Pregnant and lactating women should consult a healthcare provider before use.
  • Store in a cool, dry place, away from direct sunlight and moisture.
  • Keep out of reach of children.

Dosage

As directed by the Dietician.