Valsartan Tablets | DM Pharma

Therapeutic Indication

Hypertension

Treatment of heart failure (NYHA class II–IV)

Reduction of cardiovascular mortality post-myocardial infarction

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Valsartan

Tablet

Valsartan is an angiotensin II receptor blocker (ARB) used to lower blood pressure, improve survival in heart failure, and reduce cardiovascular mortality after myocardial infarction. It works by selectively blocking AT1 receptors, preventing vasoconstriction and aldosterone secretion.

Speciality	Antihypertensive \| ARB \| Cardiovascular
Tags	Cardiology \| General Medicine
Strength	80 mg 160 mg
Packing Size	10 Tablets

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Mechanism

Valsartan selectively blocks angiotensin II type 1 (AT1) receptors, reducing vasoconstriction, aldosterone release, and sodium retention. This leads to decreased blood pressure and improved cardiac outcomes in heart failure and post-MI patients.

Pharmacokinetics

Bioavailability: ~25%
Peak plasma concentration: 2–4 hours
Half-life: ~6 hours
Excretion: Primarily via bile; minimal renal clearance

Side Effects

Dizziness
Hypotension
Fatigue
Diarrhea
Arthralgia
Hyperkalemia (rare)

Contraindication

Pregnancy (Boxed warning: fetal toxicity)
Hypersensitivity to Valsartan or excipients
Severe hepatic impairment
Concomitant use with aliskiren in diabetic patients

Interaction

ACE inhibitors or aliskiren: ↑ risk of renal impairment & hyperkalemia
Potassium supplements/diuretics: ↑ serum potassium
NSAIDs: ↓ antihypertensive effect, possible renal impairment

Warning and Precautions

Monitor renal function in patients with kidney disease
Risk of hypotension in volume-depleted patients
Hyperkalemia risk, especially with potassium-sparing diuretics
Use caution in hepatic impairment