Proanthocyanidins Tablets

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Therapeutic Indication

Oxidative stress management
Chronic venous insufficiency
Varicose veins
Skin health and anti-aging
Cardiovascular protection
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Proanthocyanidins

Tablet

Proanthocyanidins (also called leukoanthocyanidins) are a class of natural polyphenolic bioflavonoids that are very widespread in nature. Proanthocyanidins appear to be especially effective in neutralizing highly reactive hydroxyl and singlet oxygen radicals. Both of these reactive oxygen species are involved in inflammatory processes.
Proanthocyanidins also support and enhance the activity of vitamin C, and are known for their ability to help support the health of the body's capillary system and connective tissues. Proanthocyanidins have been shown to bind with collagen fibers, thereby protecting them from premature degradation. This helps maintain the natural elasticity of collagen in skin, joints, arteries, capillaries, and other connective tissues.
This supplement helps support cardiac health by maintaining youthful endothelial function, regulating platelet aggregation, and reducing inflammation. It is a powerful protector of heart and general circulation. It favorably changes a number of metabolic signals toward reduced risk for cardiovascular disease. It is proven to act as a water-soluble antioxidant and helps lower key inflammatory signals such as CRP, IL6, and TNFa. It is also proven to act at the gene transcription level, helping clear cholesterol, reduce triglycerides, and directly helping the key inflammatory gene signal known as NF-kappaB.

Speciality Dermatology | Cardiology | General Wellness
Tags Antioxidant | Grape Seed Extract | Vascular Health | Skin Care | Nutraceutical
Strength
  • 75 mg
Packing Size
  • 10 Tablets

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Mechanism

Proanthocyanidins act by scavenging free radicals and inhibiting oxidative damage to cells. They strengthen capillary walls, improve endothelial function, and enhance microcirculation, thereby supporting cardiovascular and skin health.

Pharmacokinetics

  • Absorption: Moderately absorbed in the gastrointestinal tract
  • Distribution: Distributed in vascular tissues and skin
  • Metabolism: Metabolized into phenolic acids by gut microbiota
  • Elimination: Excreted via urine and bile
  • Half-life: Variable depending on formulation

Side Effects

  • Mild gastrointestinal discomfort
  • Headache (rare)
  • Dizziness

Contraindication

  • Hypersensitivity to grape-derived products
  • Severe bleeding disorders

Interaction

  • Anticoagulants – may enhance bleeding risk
  • Antiplatelet drugs – additive effect

Warning and Precautions

  • Use cautiously in bleeding disorders
  • Avoid during pregnancy unless prescribed
  • Consult physician before long-term use