Posaconazole Tablets

Therapeutic Indication

Prophylaxis of invasive Aspergillus and Candida infections

Treatment of oropharyngeal candidiasis

Used in immunocompromised patients (e.g., chemotherapy, transplant)

Posaconazole

Tablet

Posaconazole is a triazole antifungal agent that inhibits the synthesis of ergosterol, an essential component of fungal cell membranes. It is widely used for prophylaxis and treatment of invasive fungal infections in high-risk patients.

Speciality	Infectious Diseases \| Hematology \| Transplant Medicine
Tags	Antifungal \| Triazole \| Immunocompromised Care
Strength	100 mg
Packing Size	10 Tablets

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Mechanism

Posaconazole inhibits the fungal enzyme lanosterol 14α-demethylase, blocking ergosterol synthesis and disrupting fungal cell membrane integrity, leading to cell death.

Pharmacokinetics

Absorption: Enhanced with food intake
Metabolism: Limited hepatic metabolism (UGT1A4)
Elimination: Primarily fecal excretion
Half-life: Approximately 35 hours

Side Effects

Nausea / Vomiting
Diarrhea
Headache
QT prolongation
Hepatic enzyme elevation

Contraindication

Hypersensitivity to Posaconazole or other azoles
Concomitant use with drugs that prolong QT interval

Interaction

Cyclosporine, Tacrolimus (increased levels)
Statins (risk of myopathy)
Rifabutin, Phenytoin (reduced efficacy)

Warning and Precautions

Monitor liver function tests
Use with caution in patients with cardiac arrhythmias
Ensure adequate food intake for absorption

Dosage

As directed by the Physician.