Phytomenadione Tablets

Vildagliptin Tablet

Therapeutic Indication

Treatment of Vitamin K deficiency
Prevention of bleeding disorders (hypoprothrombinemia)
Reversal of anticoagulant therapy (e.g., warfarin overdose)
Prophylaxis in newborns against hemorrhagic disease
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Phytomenadione

Tablet

Prasugrel is an antiplatelet agent that works by inhibiting platelet activation and aggregation. It is prescribed to reduce the risk of heart attack, stroke, and other cardiovascular complications in patients with ACS undergoing PCI.

Speciality Hematology | Internal Medicine | Pediatrics
Tags Vitamin K1 | Anticoagulant Reversal | Hemostasis
Strength
  • 10 mg
Packing Size
  • 10 Tablets

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Mechanism

Phytomenadione acts as a cofactor for the gamma-carboxylation of glutamic acid residues in clotting factors II, VII, IX, and X. This process is essential for their activation and normal blood coagulation.

Pharmacokinetics

  • Absorption: Enhanced with dietary fat
  • Metabolism: Hepatic metabolism
  • Elimination: Bile and urine
  • Half-life: Short, requiring regular dosing in deficiency states

Side Effects

  • Dizziness
  • Flushing
  • Profuse sweating
  • Rapid or weak pulse
  • Rare hypersensitivity reactions

Contraindication

  • Hypersensitivity to Phytomenadione
  • Use with caution in severe liver disease

Interaction

  • Anticoagulants (warfarin) – antagonistic effect
  • Broad-spectrum antibiotics – may reduce gut flora synthesis of Vitamin K
  • Lipid-lowering agents – may impair absorption

Warning and Precautions

  • Monitor prothrombin time (PT/INR) during therapy
  • Use cautiously in pregnant and breastfeeding women
  • Avoid unsupervised supplementation with other vitamins

Dosage

As directed by the Physician.