Oxcarbazepine Tablets

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Therapeutic Indication

Chemotherapy-Induced Nausea and Vomiting (CINV)
Post-operative Nausea and Vomiting (PONV)
Radiation therapy induced nausea and vomiting
Severe Hyperemesis gravidarum
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Oxcarbazepine

Tablet

Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures. It is a structural derivative of carbamazepine and exerts a majority of its activity via a pharmacologically active metabolite, MHD. Compared to other anti-epileptic drugs, which are generally metabolized via the cytochrome P450 system, oxcarbazepine has a reduced propensity for involvement in drug-drug interactions owing to its primarily reductive metabolism.

Speciality Neurology
Tags Anti-Epileptic | Seizure Control | Anticonvulsant | Neurology Drug
Strength
  • 150 mg
  • 300 mg
  • 450 mg
  • 600 mg
Packing Size
  • 10 Tablets

Check all Tablet Range

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Mechanism

Oxcarbazepine blocks voltage-sensitive sodium channels, stabilizing hyperexcited neuronal membranes, inhibiting repetitive firing, and reducing synaptic impulse propagation.

Pharmacokinetics

  • Absorption: Rapidly and almost completely absorbed after oral administration
  • Bioavailability: High oral bioavailability
  • Distribution: Moderate protein binding (~40%)
  • Metabolism: Rapidly converted to active metabolite (MHD)
  • Half-life: Parent drug ~2 hours; active metabolite ~8–10 hours
  • Excretion: Mainly excreted in urine

Side Effects

  • Dizziness
  • Drowsiness
  • Headache
  • Nausea
  • Hyponatremia

Contraindication

  • Hypersensitivity to Oxcarbazepine
  • Severe liver impairment

Interaction

  • Oral contraceptives (reduced efficacy)
  • Other antiepileptic drugs
  • Calcium channel blockers

Warning and Precautions

  • Monitor sodium levels
  • Use cautiously in renal impairment
  • Avoid abrupt withdrawal
  • Monitor for CNS side effects