Capsule

Mechanism

Omeprazole is a proton pump inhibitor (PPI). It suppresses gastric acid secretion by inhibiting the H⁺/K⁺-ATPase proton pump in gastric parietal cells. Following activation in the acidic environment of the parietal-cell canaliculi, omeprazole inhibits the final step of gastric acid secretion. This results in a reduction in both basal and stimulated gastric acid secretion. Omeprazole is acid-labile. The enteric coating protects the drug from degradation in the acidic stomach environment and allows release after passage into the intestine, where the formulation can be absorbed. Domperidone is a peripheral dopamine D₂-receptor antagonist. It facilitates gastrointestinal motility and gastric emptying and can reduce nausea and vomiting through its peripheral antiemetic activity.

Dosage

• As directed by the physician.

Side Effects

• Headache
• Abdominal discomfort

Contraindications

• Known hypersensitivity to Omeprazole, Domperidone or any excipient.
• Known QT prolongation or significant cardiac conduction abnormalities.
• Certain underlying cardiac conditions, including clinically significant cardiac disease.
• Significant electrolyte disturbances.
• Concomitant use with medicines known to cause QT prolongation.
• Concomitant use with potent CYP3A4 inhibitors, where contraindicated.
• Severe hepatic impairment for Domperidone, where applicable.

Warning and Precautions

• Patients with significant hepatic impairment should be evaluated carefully before receiving Domperidone-containing therapy.
• Repeated administration of Domperidone may require dose/frequency adjustment in severe renal impairment.
• Keep out of reach of children.
• Store in a cool, dry place away from direct sunlight and moisture.
• Discontinue use and seek professional advice if any unusual reaction occurs.