Therapeutic Indication
| Management of Polycystic Ovary Syndrome (PCOS) |
| Improves ovulation and menstrual cycle regularity |
| Supports fertility and reproductive health |
| Promotes hormonal balance |
| Enhances insulin sensitivity and metabolic function |
| Vitamin D3 supplementation for bone and immune health |
Myo-Inositol + D-Chiro-Inositol + Vitamin D3 + Chromium
Tablet
This is a dietary supplement for women that help to manage PCOS and support fertility. This combination improves ovulatory function, menstrual cyclicity and the quality of eggs.
PCOS is the main cause of infertility due to metabolic, hormonal and ovarian dysfunctions. Women affected by PCOS often suffer of insulin resistance and of a compensatory hyperinsulinemia. These conditions put the patient at risk of developing several metabolic disorders.
Polycystic Ovarian Syndrome may be one of the most complex female health issues of our time. It is the most common endocrine disorder in women of reproductive age. PCOS is accompanied by a variety of different health issues, many of which directly impact fertility. Classic PCOS presents with obesity, polycystic ovaries (multiple ovarian cysts that look like a strand of pearls), elevated levels of androgens and absent or irregular menstrual cycles. Not all women who will go on to be diagnosed with PCOS will have these issues though.
Causes of PCOS: Poor nutrition often plays a major role, as does exposure to certain chemicals. Age plays less of a role before menopause. Many women turn to a low-fat, high fiber diet in an attempt to increase health and lose weight. Weight loss has been shown to increase fertility, but losing weight in this way is rarely effective for increasing fertility because it deprives the body of the necessary proteins and fats necessary for hormone production.
Several links including genes, possible abnormal fetal development, insulin resistance and inflammatory response are contributing to the cause. We know that insulin resistance plays a key role in PCOS, but what leads to the development of this has not been pinned down. PCOS is also negatively affected by diet, lifestyle and exposure to certain environmental toxins. PCOS directly impacts fertility, but has serious health implications as well, especially if left untreated.
Genetic Predisposition and Abnormal Fetal Development:
Women whose mothers, sisters or grandmothers had PCOS are at a higher risk for developing PCOS. Research suggests that exposure to excessive amounts of male hormones (androgens) by the developing fetus may alter proper gene expression. This means that the affected genes will not function correctly later in life, which may cause PCOS during the reproductive years of a woman's life.
Insulin Resistance:
Insulin is a hormone produced in the pancreas and is responsible for signaling cells in the body to function correctly, most importantly to convert glucose to energy and to control their growth. It also plays a key role in the metabolism of carbohydrates, lipids and proteins. Insulin resistance happens when the body's cells become resistant to the effects of insulin. When this happens, higher levels of insulin are needed so that insulin can have the proper effects. At this point, the pancreas must overcompensate, working harder and harder to produce more insulin.
Low-grade Inflammation:
It has also been found that women with PCOS have low-grade inflammation, which may be a cause for insulin resistance. White blood cells produce substances to fight infection, this is known as inflammatory response.
PCOS and Insulin Resistance:
Approximately 10% of women of reproductive age have PCOS, an endocrine disorder characterized by hormonal imbalance and often anovulation. Women with PCOS have ovaries that contain many small follicles, called cysts, which appear like a string of pearls on an ultrasound scan. A woman with PCOS does not experience the typical hormonal surge that would induce ovulation; therefore these follicles don't grow or ovulate normally and can contribute to the overproduction of the hormone testosterone.
Myo-inositol (MI) and D-chiro inositol (DCI) glycans administration has been reported to exert beneficial effects at metabolic, hormonal and ovarian level. Beside these common features, MI and DCI are indeed different molecules: they belong to two different signal cascades and regulate different biological processes.
In a study, the D-Chiro-inositol group had an improvement in insulin resistance and a 55 % reduction in testosterone levels compared to the placebo group. Significantly more women ovulated in the Chiro inositol group than in the placebo group (86% vs. 27%). D-Chiro-Inositol helps to improve insulin sensitivity, lower free and total testosterone, lower blood pressure, and increase the frequency of ovulation.
Grape seed Extract in this combination acts as an antioxidant and improves insulin sensitivity and restore redox balance in patients with PCOS.
Berberine lowers insulin and glucose level, and regulates insulin receptors and also stimulates the uptake of glucose into cells.
L-Methylfolate helps control homocysteine levels. Homocysteine is an undesirable substance in the body that is often elevated in women with PCOS.
Chromium, a trace mineral, enhances the action of insulin.
This formula also contains Vitamin D3. Vitamin D3 deficiency appears to occur in women with PCOS and may contribute to some of the biochemical abnormalities seen in this condition. Functions of Vitamin D3 include improved insulin sensitivity, better bone health, reduction of inflammation, and longer lifespan.
So, the rational use of nutritional supplements, combined with a healthy diet, will contribute substantially to health promotion and work in balance and synergism on protection and integration of the physiological functions of the body.
| Speciality | Reproductive Health | Metabolic Support | Nutritional Supplement |
|---|---|
| Tags | PCOS Support | Fertility | Hormonal Balance | Insulin Sensitivity |
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