Levosulpiride Tablets

Therapeutic Indication

Schizophrenia

Depression and anxiety disorders

Somatoform disorders

Gastroesophageal reflux disease (GERD)

Functional dyspepsia and gastrointestinal motility disorders

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Levosulpiride

Tablet

Levosulpiride is an atypical antipsychotic and prokinetic agent. It acts as a selective dopamine D2 receptor antagonist, providing antipsychotic, antidepressant, anxiolytic, and gastrointestinal motility-enhancing effects. It is widely prescribed in psychiatry and gastroenterology.

Speciality	Antipsychotic / Prokinetic Agent
Tags	Psychiatry \| Gastroenterology \| Dopamine Antagonist
Strength	25 mg 50 mg
Packing Size	10 Tablets

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Mechanism

Levosulpiride selectively blocks dopamine D2 receptors in the central nervous system and gastrointestinal tract. This provides antipsychotic and antidepressant effects while enhancing gastric emptying and intestinal motility.

Pharmacokinetics

Absorption: Rapid oral absorption
Distribution: Widely distributed, moderate protein binding
Metabolism: Minimal hepatic metabolism
Elimination: Primarily renal excretion
Half-life: ≈ 6–8 hours

Side Effects

Drowsiness
Dizziness
Hyperprolactinemia (galactorrhea, gynecomastia)
Extrapyramidal symptoms (rare)
Gastrointestinal discomfort

Contraindication

Hypersensitivity to Levosulpiride
Pregnancy and lactation
Severe renal impairment
Epilepsy

Interaction

Levodopa — antagonistic effect
CNS depressants — additive sedation
Antihypertensives — enhanced hypotensive effect
Alcohol — increases CNS side effects

Warning and Precautions

Monitor prolactin levels during prolonged therapy
Use cautiously in patients with Parkinson’s disease
Adjust dose in renal impairment