Ketoconazole Tablets

Therapeutic Indication

Systemic fungal infections

Dermatophytosis (ringworm, athlete’s foot, jock itch)

Candidiasis (oral, esophageal, systemic)

Blastomycosis, histoplasmosis, and other deep fungal infections

+91 85919 78885

Ketoconazole

Tablet

Ketoconazole is an imidazole antifungal agent used to treat systemic and superficial fungal infections. It works by inhibiting fungal cytochrome P450 enzymes, blocking ergosterol synthesis, and disrupting fungal cell membrane integrity. Ketoconazole is effective against dermatophytes, yeasts, and certain systemic fungi.

Speciality	Antifungal Agent
Tags	Antifungal \| Dermatophytosis \| Candidiasis \| Systemic Fungal Infection
Strength	200 mg
Packing Size	10 Tablets

Check all Tablet Range

Click to know More

Mechanism

Ketoconazole inhibits fungal cytochrome P450-dependent enzymes, blocking ergosterol synthesis. This leads to disruption of fungal cell membrane structure and function, resulting in fungal cell death.

Pharmacokinetics

Absorption: Oral absorption enhanced by acidic gastric environment
Distribution: Widely distributed in tissues, protein bound
Metabolism: Extensive hepatic metabolism via CYP3A4
Elimination: Primarily fecal excretion
Half-life: 6–8 hours

Side Effects

Nausea and vomiting
Abdominal pain
Pruritus and rash
Liver enzyme elevation
Rare adrenal suppression

Contraindication

Hypersensitivity to Ketoconazole
Severe hepatic impairment

Interaction

Strong CYP3A4 inhibitor — interacts with statins, anticoagulants, certain antihistamines
Antacids and proton pump inhibitors reduce absorption
Co-administration with hepatotoxic drugs increases risk of liver injury
Requires caution with immunosuppressants (e.g., cyclosporine, tacrolimus)

Warning and Precautions

Monitor liver function during therapy
Use cautiously in patients with adrenal insufficiency
Avoid alcohol during treatment (risk of hepatotoxicity)