Ipriflavone, Alfacalcidol with Calcium Carbonate Tablets

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Therapeutic Indication

Prevention and treatment of osteoporosis
Adjunct in postmenopausal bone loss
Support in calcium and vitamin D deficiency
Management of osteopenia and bone fragility
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Ipriflavone, Alfacalcidol with Calcium Carbonate

Tablet

Calcium is one of the main nutrients that the body requires in order to overcome the problems of the high blood pressure, heart attack, premenstrual syndrome and colon cancer.
One of the main health benefits of calcium is that it helps in keeping the bones strong and healthy. If blood calcium carbonate levels are too low, the body will break down bone and teeth to increase the blood calcium carbonate levels. If the blood levels are high, then the body uses the extra calcium carbonate to rebuild bone and teeth. Alfacalcidol helps is regulation of the calcium balance in body.

Calcium Carbonate is a mineral that is found naturally in foods. Calcium carbonate is necessary for many normal functions of the body, especially bone formation and maintenance. Calcium can also bind to other minerals (such as phosphate) and aids in their removal from the body.
Calcium Carbonate is used to prevent and to treat calcium deficiency. Calcium helps to keep a check on the blood pressure and also it aids in muscle contrition, thereby enabling the heart and blood vessels to perform their functioning effectively.

Alfacalcidol is an active metabolite of vitamin D, which performs important function in regulation of the calcium balance and bone metabolism. Alfacalcidol is vitamin D-hormone analog which is activated by enzyme 25-hydroxylase in the liver for systemic and in osteoblasts for local D-hormone action. It also possesses a unique pattern of the pleiotropic effects on gut, bone, parathyroid, muscle and brain.

Ipriflavone is synthetic derivative of the isoflavone, acts primarily to suppress bone resorption and prevent osteoporosis in postmenopausal women. It is used as an alternative to hormone treatments for increasing bone mass and relieving the pain of osteoporosis.

Speciality Endocrinology | Diabetology | General Medicine
Tags Sulfonylurea | Biguanide | Type 2 Diabetes | Blood Sugar Control
Strength
  • Ipriflavone 300 mg
  • Alfacalcidol 0.25 mcg
  • Calcium Carbonate 500 mg
Packing Size
  • 10 Tablets

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Mechanism

Ipriflavone inhibits bone resorption and stimulates osteoblast activity, improving bone density. Alfacalcidol, a vitamin D analogue, enhances calcium absorption and regulates bone mineralization. Calcium Carbonate provides elemental calcium to strengthen bones and prevent hypocalcemia.

Pharmacokinetics

  • Absorption: Calcium absorbed in intestine; Alfacalcidol rapidly absorbed orally.
  • Distribution: Calcium distributed to bone and extracellular fluid; Alfacalcidol binds plasma proteins.
  • Metabolism: Alfacalcidol converted in liver to active calcitriol; Ipriflavone metabolized hepatically.
  • Elimination: Calcium excreted via urine and feces; metabolites via bile.
  • Half-life: Alfacalcidol ~3–6 hrs; Calcium varies with intake.

Side Effects

  • Gastrointestinal upset
  • Nausea
  • Hypercalcemia (rare)
  • Headache

Contraindication

  • Hypersensitivity to any component
  • Hypercalcemia or hypervitaminosis D
  • Severe renal impairment

Interaction

  • Thiazide diuretics may increase risk of hypercalcemia
  • Concurrent use with digitalis may enhance toxicity
  • Antacids containing magnesium may interfere with absorption

Warning and Precautions

  • Monitor serum calcium and vitamin D levels during therapy.
  • Use cautiously in patients with renal impairment or kidney stones.
  • Long-term use requires periodic bone density evaluation.
  • Pregnant and lactating women should use only under medical advice.
  • Store in a cool, dry place away from sunlight.

Dosage

As directed by the Physician.