Gabapentin Tablets

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Therapeutic Indication

Partial seizures (epilepsy)
Neuropathic pain (post-herpetic neuralgia, diabetic neuropathy)
Fibromyalgia
Restless Leg Syndrome (RLS)
Adjunct therapy in chronic pain management
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Gabapentin

Tablet

Gabapentin is a structural analogue of gamma-aminobutyric acid (endogenous inhibitory neurotransmitter). Gabapentin is widely accepted for the treatment of epilepsy. Gabapentin is indicated for the treatment of peripheral neuropathic pain such as painful diabetic neuropathy and post-herpetic neuralgia in adults. It was originally developed as a novel anti-epileptic for the treatment of certain types of seizure.

Speciality Neurology | Pain Medicine | Psychiatry
Tags Anticonvulsant | Neuropathic Pain | Epilepsy | Fibromyalgia | Restless Leg Syndrome
Strength
  • 100 mg
  • 300 mg
Packing Size
  • 10 Tablets

Check all Tablet Range

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Mechanism

Gabapentin is a structural analogue of GABA but does not act directly on GABA receptors. It binds to the α2δ subunit of voltage-gated calcium channels in the central nervous system, reducing calcium influx and thereby decreasing excitatory neurotransmitter release. This stabilizes neuronal activity, reduces hyperexcitability, and alleviates neuropathic pain.

Pharmacokinetics

  • Absorption: Absorbed in the small intestine via L-amino acid transporters; bioavailability decreases with higher doses.
  • Distribution: Not protein-bound; widely distributed in tissues including CNS.
  • Metabolism: Not metabolized in the liver.
  • Excretion: Excreted unchanged via kidneys.
  • Half-life: 5–7 hours; requires multiple daily dosing.

Side Effects

  • Drowsiness, dizziness, fatigue.
  • Ataxia, tremors, blurred vision.
  • Weight gain, peripheral edema.
  • Gastrointestinal upset (nausea, vomiting).
  • Rare: Mood changes, suicidal ideation, hypersensitivity reactions.

Contraindication

  • Known hypersensitivity to gabapentin or excipients.
  • Severe renal impairment without dose adjustment.
  • Use with caution in patients with psychiatric disorders (risk of mood changes).

Interaction

  • Antacids (containing aluminum/magnesium) reduce gabapentin absorption.
  • Opioids (e.g., morphine) may increase gabapentin levels and sedation risk.
  • Alcohol and CNS depressants enhance sedative effects.
  • No significant hepatic metabolism interactions (safe with most drugs).

Warning and Precautions

  • Do not discontinue abruptly; taper gradually to avoid withdrawal seizures.
  • Monitor renal function; dose adjustment required in renal impairment.
  • Use with caution in elderly patients due to sedation and fall risk.
  • Monitor for mood changes or suicidal ideation.

Dosage

As directed by the Physician.