Sachet

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Benefits

Provides antibacterial activity against susceptible organisms.
Inhibits an early step in bacterial cell-wall synthesis.
Administered orally as granules for oral solution.
The approved oral formulation is used for acute uncomplicated cystitis caused by susceptible organisms.
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Fosfomycin Tromethamine

SACHET

Fosfomycin Tromethamine is an oral antibacterial medicine that is converted to active fosfomycin after administration. It acts by inhibiting an early step in bacterial cell-wall synthesis. The oral granule formulation is used for appropriately susceptible bacterial infections, with current prescribing information specifically indicating it for acute uncomplicated cystitis in adult women caused by susceptible strains of Escherichia coli and Enterococcus faecalis. It is not indicated for pyelonephritis or perinephric abscess in that prescribing information.

Speciality Anti-Infective | Urology
Tags Fosfomycin Tromethamine | Antibacterial | Antibiotic | Oral Antibacterial | Prescription Medicine
Strength

    Fosfomycin Tromethamine BP

  • Eq. to Fosfomycin — 3 gm
  • Excipients — q.s.
Packing Size
  • 10 x 1 x 8 gm

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Mechanism of Action

Fosfomycin is a bactericidal antibacterial agent that inhibits an early and essential step in bacterial cell-wall synthesis. It is transported into susceptible bacterial cells through specific uptake systems and then binds covalently to UDP-N-acetylglucosamine enolpyruvyl transferase (MurA). This enzyme is required for the initial stage of peptidoglycan synthesis, an essential component of the bacterial cell wall. By inhibiting MurA, fosfomycin blocks peptidoglycan formation, resulting in disruption of bacterial cell-wall synthesis and subsequent bacterial cell death.

Indications

    Fosfomycin Tromethamine is indicated for the treatment of acute uncomplicated cystitis in adult women caused by susceptible bacterial strains, according to the approved prescribing information.

Dosage

  • As directed by the Physician.

Side Effects

  • Abdominal discomfort
  • nausea
  • Vaginitis

Contraindication

  • Known hypersensitivity to fosfomycin tromethamine or any component of the formulation.

Directions for Use:

  • Fosfonik should be taken orally.
  • Fosfonik may be taken with or without food.
  • Pour the entire contents of a single dose sachet into a glass of water (90-120 ml) and stir to dissolve.
  • Do not use hot water.
  • It should be taken immediately after dissolving in water.
  • Before taking Fosfonik, always mix with water.

Warning and Precautions

  • Use only under the supervision of a qualified healthcare professional.
  • Use only for infections caused by susceptible organisms.
  • Do not use for pyelonephritis unless specifically directed by the treating physician and supported by the approved indication.
  • Consider previous antibiotic exposure and local antimicrobial susceptibility when clinically appropriate.
  • Severe or persistent diarrhoea should be medically evaluated because antibiotic-associated colitis can occur.
  • Store in a cool, dry & dark place.
  • Patients with known hypersensitivity to fosfomycin should not use the product.
  • Avoid unnecessary antibiotic use to help reduce antimicrobial resistance.
  • Inform the healthcare professional about other medicines and existing medical conditions.
  • Protect from direct sunlight and heat.

Disclaimer

All product details on this website are for reference and informational purposes only and are not directed at patients or consumers.
As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
Please consult a healthcare professional before using any medicinal product.