Etoricoxib +
Thiocolchicoside Tablets

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Therapeutic Indication

Acute musculoskeletal pain
Low back pain & sciatica
Cervical spondylosis
Post-traumatic muscle spasm
Osteoarthritis & rheumatoid arthritis
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Etoricoxib + Thiocolchicoside

Tablet

Etoricoxib + Thiocolchicoside is a combination of a selective COX-2 inhibitor and a muscle relaxant used for effective management of pain associated with muscle spasm. Etoricoxib provides potent anti-inflammatory and analgesic action, while Thiocolchicoside relieves muscle stiffness and spasm, improving mobility and comfort. This combination is widely used in conditions like back pain, cervical pain, arthritis, and post-traumatic muscle spasm.

Speciality COX-2 Inhibitor | Muscle Relaxant
Tags Pain Relief | Anti-inflammatory | Muscle Relaxant
Strength
  • Etoricoxib 60 mg
  • Thiocolchicoside 4 mg
Packing Size
  • 10 Tablets

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Mechanism

Etoricoxib + Thiocolchicoside acts through a dual and synergistic mechanism to provide superior pain relief and muscle relaxation. Etoricoxib selectively inhibits cyclooxygenase-2 (COX-2) enzyme, reducing prostaglandin synthesis responsible for inflammation, pain, and swelling, with minimal gastric side effects compared to non-selective NSAIDs.
Thiocolchicoside acts centrally on GABA-A and glycine receptors in the spinal cord, producing muscle relaxation and reducing painful muscle spasms without significant sedation. The combination ensures rapid reduction of inflammation and effective relief from muscle spasm, leading to improved mobility, faster recovery, and better patient comfort in musculoskeletal disorders.

Pharmacokinetics

  • Absorption: Rapidly absorbed after oral administration.
  • Distribution: Highly protein bound.
  • Metabolism: Hepatic metabolism.
  • Elimination: Excreted via urine and feces.

Side Effects

  • Nausea
  • Dizziness
  • Gastric discomfort
  • Headache

Contraindication

  • Hypersensitivity to COX-2 inhibitors or NSAIDs
  • Severe hepatic or renal impairment
  • Peptic ulcer disease
  • Pregnancy and lactation

Interaction

  • Anticoagulants (increased bleeding risk)
  • Other NSAIDs
  • ACE inhibitors & diuretics
  • Alcohol

Warning and Precautions

  • Use cautiously in cardiovascular disease patients
  • Monitor liver and kidney function
  • Avoid long-term use without supervision
  • Use only under medical advice