Etoricoxib Tablets

Mechanism

Etoricoxib selectively inhibits cyclooxygenase-2 (COX-2), an enzyme responsible for prostaglandin synthesis involved in pain and inflammation. By blocking COX-2, it reduces inflammation and provides analgesic effects while sparing COX-1, thus minimizing gastrointestinal side effects.

Pharmacokinetics

• Absorption: Rapidly absorbed with high oral bioavailability.
• Distribution: Highly protein bound (~92%).
• Metabolism: Extensively metabolized in the liver.
• Elimination: Excreted via urine and feces.
• Half-life: Approximately 22 hours.

Side Effects

• Headache
• Dizziness
• Edema (fluid retention)
• Hypertension
• Gastrointestinal discomfort

Contraindication

• Hypersensitivity to etoricoxib or NSAIDs
• Active peptic ulcer or gastrointestinal bleeding
• Severe hepatic impairment
• Severe renal impairment
• Established cardiovascular disease (e.g., ischemic heart disease, stroke)
• Pregnancy and lactation

Interaction

• Anticoagulants (e.g., warfarin): Increased bleeding risk
• ACE inhibitors & ARBs: Reduced antihypertensive effect
• Diuretics: Reduced diuretic efficacy
• Other NSAIDs: Increased risk of adverse effects
• Lithium: Increased lithium levels

Warning and Precautions

This has been prescribed for the patient's specific condition. It may be dangerous to any other person.

• Use the lowest effective dose for the shortest duration
• Monitor blood pressure regularly
• Use cautiously in patients with cardiovascular risk
• Monitor renal and hepatic function during long-term use
• Avoid use in severe heart disease patients

Dosage

As directed by the Physician.