Divalproex Tablets

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Therapeutic Indication

Epilepsy (partial and generalized seizures)
Bipolar disorder (manic episodes)
Migraine prophylaxis
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Divalproex

Tablet

Divalproex ER is a valproate derivative used as an anticonvulsant and mood stabilizer. It provides sustained plasma levels for once‑daily dosing, improving compliance in epilepsy, bipolar disorder, and migraine prevention.

Speciality Cardiology | Vascular Medicine
Tags Neurology | Psychiatry
Strength
  • 250 mg ER
  • 500 mg ER
  • 750 mg ER
  • 1000 mg ER
Packing Size
  • 10 Tablets

Check all Tablets Range

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Mechanism

Divalproex increases brain levels of gamma‑aminobutyric acid (GABA) by inhibiting GABA transaminase and blocking voltage‑gated sodium channels. This stabilizes neuronal activity, reducing seizures and mood fluctuations.

Pharmacokinetics

  • Absorption: Well absorbed orally; extended release formulation provides sustained plasma levels.
  • Bioavailability: ~90% for ER tablets.
  • Distribution: Highly protein bound (~90% to albumin); volume of distribution ~0.1–0.4 L/kg.
  • Metabolism: Extensively metabolized in the liver via glucuronidation and mitochondrial β‑oxidation.
  • Excretion: Eliminated mainly in urine as metabolites; <10% excreted unchanged.
  • Half-life: ~9–16 hours, prolonged with ER formulation allowing once‑daily dosing.

Side Effects

  • Headache
  • Palpitations
  • Dizziness
  • Diarrhea
  • Peripheral edema

Contraindication

  • Hepatic impairment
  • Hypersensitivity to valproate derivatives
  • Pregnancy (risk of teratogenicity)

Interaction

  • Other antiepileptics (phenytoin, carbamazepine alter plasma levels)
  • Aspirin (displaces protein binding)
  • CNS depressants (additive sedation)

Warning and Precautions

  • Use under medical supervision only
  • Monitor for bleeding complications
  • Not recommended in patients with heart failure

Dosage

As directed by the Physician.