Cissus Quadrangularis + Vitamin D3 Tablets

Mechanism

Cissus Quadrangularis: Supports bone healing, reduces inflammation, and promotes collagen synthesis.
Vitamin D3: Enhances calcium absorption, maintains bone mineral density, and supports immune function.

Pharmacokinetics

• Absorption: Vitamin D3 absorbed in the small intestine with dietary fat; Cissus acts locally and systemically.
• Distribution: Vitamin D3 stored in fat and muscle; Cissus distributed to connective tissues.
• Metabolism: Vitamin D3 metabolized in the liver and kidneys; Cissus undergoes partial metabolism.
• Elimination: Vitamin D3 excreted via bile and feces; Cissus metabolites excreted renally and fecally.
• Half-life: Vitamin D3 ~15 days; Cissus varies depending on active compounds.

Side Effects

• Mild gastrointestinal discomfort
• Nausea
• Constipation (Vitamin D3)
• Rare: Hypercalcemia (Vitamin D3 overdose)
• Allergic reactions (rare, Cissus)

Contraindication

• Hypersensitivity to Cissus or Vitamin D3
• Severe renal impairment
• Hypercalcemia or hypervitaminosis D
• Pregnancy and lactation (use with medical advice)

Interaction

• Calcium supplements (risk of hypercalcemia with Vitamin D3)
• Glucocorticoids (reduce Vitamin D3 efficacy)
• Anticonvulsants (increase Vitamin D3 metabolism)
• Other herbal supplements (possible additive effects with Cissus)

Warning and Precautions

• Use under medical supervision only
• Monitor calcium and Vitamin D levels during therapy
• Discontinue if signs of hypercalcemia occur
• Advise patients to avoid excessive Vitamin D supplementation