Cissus Quadrangularis + Moringa Oleifera + Combination Tablets

Mechanism

• Cissus Quadrangularis: Promotes bone healing, enhances osteoblast activity, and reduces inflammation.
• Moringa Oleifera: Rich in antioxidants and minerals; supports immunity and bone strength.
• Withania Somnifera: Adaptogen; reduces stress, supports muscle strength, and improves recovery.
• Calcium & Magnesium: Essential minerals for bone mineralization and neuromuscular function.
• Vitamin K2-7: Directs calcium to bones, prevents vascular calcification.

Pharmacokinetics

• Absorption: Herbal extracts absorbed in intestine; calcium and magnesium absorption enhanced with Vitamin D.
• Distribution: Minerals stored in bone and muscle; herbal actives distributed systemically.
• Metabolism: Herbal actives metabolized in liver; minerals incorporated into bone matrix.
• Excretion: Calcium and magnesium excreted via urine and feces; herbal metabolites via urine and bile.
• Half-life: Variable depending on component; Vitamin K2-7 ~2–3 days.

Side Effects

• Mild gastrointestinal upset
• Headache or dizziness (rare)
• Hypercalcemia with prolonged high-dose use

Contraindication

• Hypercalcemia
• Vitamin D toxicity
• Severe renal impairment
• Hypersensitivity to herbal components

Interaction

• Anticoagulants: Vitamin K2-7 may reduce efficacy of warfarin.
• Bisphosphonates: Calcium may interfere with absorption; separate dosing recommended.
• Diuretics: Thiazides increase calcium retention; loop diuretics increase calcium loss.
• Antidiabetic drugs: Ashwagandha may enhance hypoglycemic effect.

Warning and Precautions

• Monitor serum calcium levels during therapy.
• Use with caution in patients with kidney disease.
• Pregnancy/lactation: Supplementation only under medical supervision.
• Separate dosing from iron and bisphosphonates to avoid absorption interference.

Dosage

As directed by the Dietician .