Cefpodoxime +
Dicloxacillin Tablets

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Therapeutic Indication

Skin and soft tissue infections
Respiratory tract infections
Wound infections
Bone and joint infections
Post-surgical infections
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Cefpodoxime + Dicloxacillin

Tablet

Cefpodoxime and Dicloxacillin is a dual antibiotic combination that provides enhanced antibacterial coverage against both Gram-positive and Gram-negative organisms. Cefpodoxime, a third-generation cephalosporin, inhibits bacterial cell wall synthesis, while Dicloxacillin, a penicillinase-resistant penicillin, is highly effective against penicillin-resistant staphylococci. This combination is particularly useful in treating skin, respiratory, and mixed bacterial infections, ensuring faster recovery and improved clinical outcomes.

Speciality Dual Antibiotic Combination
Tags Skin Infection | Broad Spectrum | Anti-Staphylococcal<
Strength
  • Cefpodoxime 200 mg
  • Dicloxacillin 500 mg
Packing Size
  • 10 Tablets

Check all Tablets Range

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Mechanism

Cefpodoxime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell death. Dicloxacillin resists degradation by beta-lactamase enzymes produced by resistant bacteria and also inhibits cell wall synthesis. Together, they provide synergistic bactericidal activity, especially against beta-lactamase producing organisms and mixed infections.

Pharmacokinetics

  • Absorption: Well absorbed orally (better with food)
  • Distribution: Good tissue penetration
  • Metabolism: Partial hepatic metabolism
  • Elimination: Mainly via kidneys
  • Half-life: Cefpodoxime ~2–3 hrs, Dicloxacillin ~1–2 hrs

Side Effects

  • Nausea
  • Diarrhea
  • Allergic reactions
  • Abdominal discomfort

Contraindication

  • Hypersensitivity to cephalosporins or penicillins
  • History of severe allergic reactions to beta-lactam antibiotics

Interaction

  • Probenecid (increases antibiotic levels)
  • Anticoagulants (may enhance effect)
  • Other nephrotoxic drugs

Warning and Precautions

  • Use cautiously in renal impairment
  • Monitor for allergic reactions
  • Complete full antibiotic course
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