Cefixime + Ofloxacin Tablets

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Therapeutic Indication

Respiratory tract infections
Urinary tract infections
Gastrointestinal infections
Skin and soft tissue infections
Mixed bacterial infections
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Cefixime + Ofloxacin

Tablet

Cefixime Trihydrate is an oral third generation cephalosporin antibiotic used to treat infections caused by bacteria such as pneumonia; bronchitis; gonorrhea; and ear, lung, throat, and urinary tract infections.Cefixime is used to treat many different types of infections caused by bacteria. Cefixime may also be used for other purposes not listed in this medication guide.
Ofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone.

Speciality Internal Medicine | Gastroenterology | Infectious Diseases
Tags Antibiotic | Cephalosporin | Fluoroquinolone | Mixed Infections
Strength
  • Cefixime 100 mg/200 mg
  • Ofloxacin 100 mg/200 mg
Packing Size
  • 10 Tablets

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Mechanism

This tablet is one of the combination of cefixime (cephalosporin) and ofloxacin (fluoroquinolone) and has unique dual mode of action i.e in this combination ofloxacin prevents nucleic acid synthesis of bacteria and cefixime inhibits bacterial cell wall synthesis.It is useful for killing thr ESBL (Extended Spectrum Beta-lactamase) bacteria.Both works instantly and synergistically and gives better patient compliance. Cefixime is an antibiotic, is a third generation cephalosporin like ceftriaxone and Cefotaxime.Cefixime is highly stable in the presence of beta lactamases enzymes.Cefixime is an effective treatment to stop the spread of several bacterial infections. It is often used as a treatment for gonorrhea, pharyngitis, typhoid fever and tonsillitis.ofloxacin belongs to fluoroquinolones group of antimicrobials i.e.-These are the quinolones having one or more fluorine substitution in their structure.Ofloxacin used to treat pneumonia and bronchitis caused by H.influenzae and S.pneumoniae.It is also used in treating skin infections caused by staphylococcus aureus and streptococcus pyogenes bacteria.

Pharmacokinetics

  • Absorption: Cefixime ~40–50% oral bioavailability; Ofloxacin rapidly absorbed with ~95% bioavailability.
  • Distribution: Both widely distributed in body tissues and fluids.
  • Metabolism: Cefixime minimally metabolized; Ofloxacin partially metabolized in liver.
  • Excretion: Cefixime via urine and feces; Ofloxacin primarily via urine.
  • Half-life: Cefixime ~3–4 hours; Ofloxacin ~4–5 hours.

Side Effects

  • Diarrhea
  • Nausea, vomiting
  • Abdominal pain
  • Dizziness, headache
  • Skin rash (rare)

Contraindication

  • Hypersensitivity to cephalosporins or fluoroquinolones
  • History of tendon disorders related to fluoroquinolone use
  • Pregnancy and lactation (unless prescribed)

Interaction

  • Anticoagulants: Cephalosporins may enhance anticoagulant effect.
  • Antacids: May reduce absorption of Ofloxacin.
  • NSAIDs: May increase risk of CNS stimulation and seizures with fluoroquinolones.

Warning and Precautions

  • Monitor liver and renal function during prolonged therapy.
  • Use with caution in patients with CNS disorders.
  • Avoid excessive sun exposure due to risk of photosensitivity.
  • Discontinue if severe allergic reaction occurs.

Dosage

As directed by the Physician.