Calcium Citrate + Calcium Aspartate + Calcium Orotate + Vitamin D3 Tablets

Mechanism

Calcium can be used in conditions like low calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and certain muscle disease (latent tetany). Calcium in body is necessary for strong bones, muscle contraction, nervous system, and heart. Calcium carbonate also is used as an antacid to relieve heartburn, acid indigestion, and upset stomach.

Calcium Aspartate is a calcium salt of the amino acid, aspartic acid, that has a neutral reaction in the body.Aspartatic acid is considered a non-essential amino acid, meaning that, under normal physiological conditions, sufficient amounts of the amino acid are synthesized in the body to meet the body's requirements. L-aspartate is formed by the transamination of the Krebs cycle intermediate oxaloacetate. The amino acid serves as a precursor for synthesis of proteins, oligopeptides, purines, pyrimidines, nucleic acids and L-arginine. L-aspartate is a glycogenic amino acid, and it can also promote energy production via its metabolism in the Krebs cycle. These latter activities were the rationale for the claim that supplemental aspartate has an anti-fatigue effect on skeletal muscle, a claim that was never confirmed. There are also claims that L-aspartate has ergogenic effects, that it enhances performance in both prolonged exercise and short intensive exercise. It is hypothesized that L-aspartate, especially the potassium magnesium aspartate salt, spares stores of muscle glycogen and/or promotes a faster rate of glycogen resynthesis during exercise. It has also been hypothesized that L-aspartate can enhance short intensive exercise by serving as a substrate for energy production in the Krebs cycle and for stimulating the purine nucleotide cycle.

Vitamin D3 helps your body absorb calcium. Vitamin D3 is used as a dietary supplement in people who do not get enough vitamin D in their diets to maintain adequate health. Vitamin D is used to treat and prevent bone disorders (such as rickets, osteomalacia).

Pharmacokinetics

• Calcium Citrate: Rapidly absorbed in the gastrointestinal tract with ~25–30% bioavailability. Absorption is enhanced in acidic environments and independent of gastric acid secretion, making it suitable for elderly patients. Distributed primarily to bone and teeth; plasma calcium tightly regulated by parathyroid hormone. Excreted via urine and feces; excess intake may lead to hypercalciuria.
• Calcium Aspartate: Absorbed efficiently due to chelation with aspartic acid. Aspartate enters the Krebs cycle, supporting energy metabolism and protein synthesis. Distribution includes skeletal muscle and bone. Metabolized minimally; excreted via urine.
• Calcium Orotate: Absorbed in the intestine with moderate bioavailability. Orotic acid acts as a carrier, facilitating calcium transport into cells and enhancing bone mineralization. Distributed to bone matrix and connective tissue. Excreted via urine and bile.
• Vitamin D3 (Cholecalciferol): Absorbed in the small intestine with dietary fat; requires bile salts for optimal absorption. Transported via chylomicrons to the liver, where it is hydroxylated to 25-hydroxyvitamin D3. Further hydroxylated in the kidney to active 1,25-dihydroxyvitamin D3 (calcitriol). Half-life of 25-hydroxyvitamin D3 is ~15 days, while calcitriol has a half-life of 6–8 hours. Excreted mainly via bile into feces.

Side Effects

• Gastrointestinal discomfort
• Nausea
• Dizziness
• Skin rash (rare)
• Muscle weakness (rare with Tolperisone)

Contraindication

• Hypersensitivity to NSAIDs or Tolperisone
• Severe hepatic or renal impairment
• History of gastrointestinal bleeding or peptic ulcer
• Pregnancy and lactation (use with caution)

Interaction

• Alcohol (reduces absorption)
• Antibiotics (tetracyclines, fluoroquinolones – reduced absorption)
• Diuretics (risk of hypercalcemia)

Warning and Precautions

• Use under medical supervision only
• Monitor calcium levels in long-term therapy
• Do not exceed recommended dose