Pregabalin is an anticonvulsant drug used for neuropathic pain and as an adjunct therapy for partial seizures with or without secondary generalization in adults. Methylcobalamin is the neurologically active form of vitamin B12. Vitamin B12 comes in several kinds including hydroxy, cyano, and adenosyl, but only the methyl and adenosyl forms are active within the body. Methylcobalamin donates methyl groups to the myelin sheath that insulates nerve fibres and regenerates damaged neurons. In a B12 deficiency, toxic fatty acids destroy the myelin sheath but high enough doses of B12 can repair it. It has been demonstrated by recent studies that combination of Pregabalin and Methylcobalamin shows significantly better symptoms relief with the modest improvement of nervous system, chronic pain, perioperative pain, migraine and enhances immune system function.
Indications:
● It is used for neuropathic pain associated with spinal cord injury
● Diabetic peripheral neuropathy
● Treatment of fibromyalgia
● It is also used for treatment of chronic pain, perioperative pain, and migraine
● Supports the nervous system
● Helps memory and learning
● Boosts energy
● Helps control homocysteine levels
● Promotes a healthy cardiovascular system
● Enhances immune system function
● Effectively supports brain and nerve function

Pharmacology:

Pharmacodynamic Properties of Pregabalin
Pregabalin is a structural analog of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). It has been reported that its action presents the function of modulating the release of many excitatory neurotransmitters such as glutamate, norepinephrine, subtance-P and calcitonin gene related peptide. This modulation can cause an inhibitory modulation of overexcited neurons allowing them to get back to a normal state, including the decrease on the hyper excitability caused by tissue damage. The neurotransmitter modulation allows pregabalin to present antiallodynic, anxiolytic and anticonvulsant activity.
Pharmacokinetic Properties Of Pregabalin

• Absorption:
  Pregabalin is rapidly absorbed when administered on an empty stomach, with peak plasma concentrations occurring within one hour. Pregabalin oral bioavailability is estimated to be greater than or equal to 90% and is independent of dose. The rate of pregabalin absorption is decreased when given with food resulting in a decrease in Cmax by approximately 25 to 30% and a delay in Tmax (time to reach Cmax) to approximately 3 hours. Administration with food, however, has no clinically significant effect on the extent of absorption.
• Distribution:
  Pregabalin has been shown to cross the blood–brain barrier in mice, rats, and monkeys. Pregabalin has been shown to cross the placenta in rats and is present in the milk of lactating rats. In humans, the volume of distribution of pregabalin for an orally administered dose is approximately 0.56 L/kg and is not bound to plasma proteins.
• Metabolism:
  Pregabalin undergoes negligible metabolism in humansIn experiments using nuclear medicine techniques, it was revealed that approximately 98% of the radioactivity recovered in the urine was unchanged pregabalin. The major metabolite is N-methylpregabalin.
• Excretion:
  Pregabalin is eliminated from the systemic circulation primarily by renal excretion as unchanged drug.

Pharmacodynamic Properties of Methylcobalamin
Methylcobalamin (Vitamin B12), which is used for the treatment of pernicious anaemia, and nutritional deficiencies of vitamin B12 which results in macrocytic anaemia.
Pharmacokinetic Properties of Methylcobalamin
The absorption of cobalamins from the gut is dependent upon the glycoprotein intrinsic factor. Cobalamins are transported rapidly into the blood bound to protein, known as transcobalamins. Cobalamins are stored in the liver and excreted in the bile. They are known to cross the placenta.

Pregnant & Lactating:
Although our product is safe to use but pregnant and lactating women should use it under the supervision of the physician.
Contraindications:
Pregabalin is contraindicated in patients with known hypersensitivity to pregabalin or any of its components. Vitamin B12 supplementation is generally regarded as safe during pregnancy and lactation.
Side Effects:

• Dizziness
• Drowsiness
• Dry mouth
• Constipation